(2-bromo-5-chlorophenyl)(methyl)sulfane

Base Information

• Chemical Name: (2-bromo-5-chlorophenyl)(methyl)sulfane
• CAS No.: 255051-34-4
• Molecular Formula: C₇H₆BrClS
• Molecular Weight: 237.548
• Mol file: 255051-34-4.mol

Synonyms:(2-bromo-5-chlorophenyl)(methyl)sulfane

Chemical Property of (2-bromo-5-chlorophenyl)(methyl)sulfane

Chemical Property:

• Boiling Point: 257.0±30.0 °C(Predicted)
• Density: 1?+-.0.1 g/cm3(Predicted)

Purity/Quality:

98.5% ^*data from raw suppliers

(2-Bromo-5-chlorophenyl)(methyl)sulfane 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-bromo-5-chlorophenyl)(methyl)sulfane

There total 2 articles about (2-bromo-5-chlorophenyl)(methyl)sulfane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

Dimethyldisulphide (624-92-0) + 2-bromo-5-chloroaniline (823-57-4) → (2-bromo-5-chlorophenyl)(methyl)sulfane (255051-34-4)

Guidance literature:

With tert.-butylnitrite; In acetonitrile; at 60 ℃; for 3h;

Reference yield:

2-chloro-5-bromonitrobenzene (41513-04-6) → (2-bromo-5-chlorophenyl)(methyl)sulfane (255051-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium formate; zinc / methanol; water / 50 °C

2: tert.-butylnitrite / acetonitrile / 2.25 h / 60 °C

With tert.-butylnitrite; ammonium formate; zinc; In methanol; water; acetonitrile;

Reference yield: 85.0%

(2-bromo-5-chlorophenyl)(methyl)sulfane (255051-34-4) + C18H19BN2O2 → C19H13ClN2S

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydroxide; In tetrahydrofuran; water; at 80 ℃;

upstream raw materials:

Dimethyldisulphide

2-bromo-5-chloroaniline

2-chloro-5-bromonitrobenzene

Refernces

• 1、 -. "GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF". Page/Page column 70. . Retrieved 2009/12/28.