(E)-ethyl 3-(3-methoxy-4-((3,5,6-trimethylpyrazin-2-yl)methoxy)phenyl)acrylate

Base Information

Chemical Name:(E)-ethyl 3-(3-methoxy-4-((3,5,6-trimethylpyrazin-2-yl)methoxy)phenyl)acrylate
CAS No.:1018438-90-8
Molecular Formula:C₂₀H₂₄N₂O₄
Molecular Weight:356.422
Hs Code.:

Synonyms:(E)-ethyl 3-(3-methoxy-4-((3,5,6-trimethylpyrazin-2-yl)methoxy)phenyl)acrylate

Suppliers and Price of (E)-ethyl 3-(3-methoxy-4-((3,5,6-trimethylpyrazin-2-yl)methoxy)phenyl)acrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-ethyl 3-(3-methoxy-4-((3,5,6-trimethylpyrazin-2-yl)methoxy)phenyl)acrylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (E)-ethyl 3-(3-methoxy-4-((3,5,6-trimethylpyrazin-2-yl)methoxy)phenyl)acrylate

There total 2 articles about (E)-ethyl 3-(3-methoxy-4-((3,5,6-trimethylpyrazin-2-yl)methoxy)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.7%

: 4046-02-0
ethyl 4-hydroxy-3-methoxycinnamate

: 79074-45-6
2-(bromomethyl)-3,5,6-trimethylpyrazine

: 1018438-90-8
(E)-ethyl 3-(3-methoxy-4-((3,5,6-trimethylpyrazin-2-yl)methoxy)phenyl)acrylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 85 ℃; for 8h;

Reference yield:

: 1135-24-6,537-98-4
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

: 1018438-90-8
(E)-ethyl 3-(3-methoxy-4-((3,5,6-trimethylpyrazin-2-yl)methoxy)phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 24 h / Reflux

2: tetrabutylammomium bromide; potassium carbonate / N,N-dimethyl-formamide / 6 h / 60 °C

With thionyl chloride; tetrabutylammomium bromide; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.09.030

Reference yield: 94.6%

: 1018438-90-8
(E)-ethyl 3-(3-methoxy-4-((3,5,6-trimethylpyrazin-2-yl)methoxy)phenyl)acrylate

: 1018438-91-9
(E)-3-(3-methoxy-4-((3,5,6-trimethylpyrazin-2-yl)methoxy)phenyl)acrylic acid

Guidance literature:: (E)-ethyl 3-(3-methoxy-4-((3,5,6-trimethylpyrazin-2-yl)methoxy)phenyl)acrylate; With water; sodium hydroxide; In ethanol; at 20 ℃; for 4h;

With hydrogenchloride; In water; pH=4 - 5; Cooling;