7-fluoro-5-methyl-1-[(4-nitrophenyl)sulfonyl]-1H-indole

Base Information

Chemical Name:7-fluoro-5-methyl-1-[(4-nitrophenyl)sulfonyl]-1H-indole
CAS No.:1234779-88-4
Molecular Formula:C₁₅H₁₁FN₂O₄S
Molecular Weight:334.328
Hs Code.:

Synonyms:7-fluoro-5-methyl-1-[(4-nitrophenyl)sulfonyl]-1H-indole

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Chemical Property of 7-fluoro-5-methyl-1-[(4-nitrophenyl)sulfonyl]-1H-indole

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Technology Process of 7-fluoro-5-methyl-1-[(4-nitrophenyl)sulfonyl]-1H-indole

There total 11 articles about 7-fluoro-5-methyl-1-[(4-nitrophenyl)sulfonyl]-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 442910-91-0
7-fluoro-5-methyl-1H-indole

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1234779-88-4
7-fluoro-5-methyl-1-[(4-nitrophenyl)sulfonyl]-1H-indole

Guidance literature:: 7-fluoro-5-methyl-1H-indole; With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In toluene; at 15 ℃;

4-Nitrobenzenesulfonyl chloride; In toluene; at 20 ℃;
DOI:10.1021/op300249q

Reference yield:

: 452-80-2
2-fluoro-4-methylaniline

: 1234779-88-4
7-fluoro-5-methyl-1-[(4-nitrophenyl)sulfonyl]-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride; boron trichloride; sodium hydroxide / dichloromethane; water / 14 h / Inert atmosphere; Reflux

2.1: sodium tetrahydroborate / water; pentan-1-ol / 2.42 h / 20 °C / Reflux

3.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / toluene / 15 °C

3.2: 20 °C

With aluminum (III) chloride; sodium tetrahydroborate; tetra(n-butyl)ammonium hydrogensulfate; boron trichloride; sodium hydroxide; In dichloromethane; pentan-1-ol; water; toluene;
DOI:10.1021/op300249q

Reference yield:

: 18349-09-2
2-bromo-6-fluoro-4-methyl aniline

: 1234779-88-4
7-fluoro-5-methyl-1-[(4-nitrophenyl)sulfonyl]-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Methyldicyclohexylamine / toluene / 2 h / Inert atmosphere

1.2: 72 - 75 °C / Inert atmosphere

2.1: trifluoroacetic acid / methanol; toluene; tetrahydrofuran / 5 h / 30 - 85 °C

3.1: sodium hydroxide; tetra(n-butyl)ammonium hydroxide

With N-Methyldicyclohexylamine; tetra(n-butyl)ammonium hydroxide; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; toluene; 1.1: |Sonogashira Cross-Coupling / 1.2: |Sonogashira Cross-Coupling;
DOI:10.1021/op300249q