methyl 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-oxobutanoate

Base Information

• Chemical Name: methyl 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-oxobutanoate
• CAS No.: 922366-36-7
• Molecular Formula: C₂₂H₂₄F₂N₂O₃
• Molecular Weight: 402.441
• Mol file: 922366-36-7.mol

Synonyms:methyl 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-oxobutanoate

Chemical Property of methyl 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-oxobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-oxobutanoate

There total 1 articles about methyl 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

methyl hydrogen succinate (3878-55-5) + 1-(4-fluorophenyl)methyl-piperazine (27469-60-9) → methyl 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-oxobutanoate (922366-36-7)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane;

DOI:10.1021/jm200383j

Reference yield: 100.0%

methyl 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-oxobutanoate (922366-36-7) → potassium 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-oxobutanoate (1350551-16-4)

Guidance literature:

With potassium hydroxide; In methanol;

DOI:10.1021/jm200383j

Reference yield:

methyl 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-oxobutanoate (922366-36-7) → 1-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-(isoindolin-2-yl)butane-1,4-dione (1326218-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / methanol

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; potassium hydroxide; In methanol; dichloromethane;

DOI:10.1021/jm200383j

upstream raw materials:

methyl hydrogen succinate

1-(4-fluorophenyl)methyl-piperazine

Downstream raw materials:

potassium 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-oxobutanoate

1-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-(isoindolin-2-yl)butane-1,4-dione