(1R,2S,4S,5S)-4-[2-IODO-6-(METHYLAMINO)-9H-PURIN-9-YL]-2-(PHOSPHONOOXY)BICYCLO[3.1.0]HEXANE-1-METHANOL DIHYDROGEN PHOSPHATE ESTER TETRAAMMONIUM SALT

Base Information

Chemical Name:(1R,2S,4S,5S)-4-[2-IODO-6-(METHYLAMINO)-9H-PURIN-9-YL]-2-(PHOSPHONOOXY)BICYCLO[3.1.0]HEXANE-1-METHANOL DIHYDROGEN PHOSPHATE ESTER TETRAAMMONIUM SALT
CAS No.:779323-43-2
Molecular Formula:C₁₃H₁₈IN₅O₈P₂
Molecular Weight:561.167
Hs Code.:
Mol file:779323-43-2.mol

(1R,2S,4S,5S)-4-[2-IODO-6-(METHYLAMINO)-9H-PURIN-9-YL]-2-(PHOSPHONOOXY)BICYCLO[3.1.0]HEXANE-1-METHANOL DIHYDROGEN PHOSPHATE ESTER TETRAAMMONIUM SALT

Synonyms:Bicyclo[3.1.0]hexane-1-methanol,4-[2-iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)-, dihydrogenphosphate (ester), (1R,2S,4S,5S)- (9CI); MRS 2500

Suppliers and Price of (1R,2S,4S,5S)-4-[2-IODO-6-(METHYLAMINO)-9H-PURIN-9-YL]-2-(PHOSPHONOOXY)BICYCLO[3.1.0]HEXANE-1-METHANOL DIHYDROGEN PHOSPHATE ESTER TETRAAMMONIUM SALT

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
MRS 2500 tetraammonium salt
1mg
$ 909.00

Tocris
MRS2500tetraammoniumsalt ≥96%(HPLC)
1
$ 368.00

American Custom Chemicals Corporation
(1R,2S,4S,5S)-4-[2-IODO-6-(METHYLAMINO)-9H-PURIN-9-YL]-2-(PHOSPHONOOXY)BICYCLO[3.1.0]HEXANE-1-METHANOL DIHYDROGEN PHOSPHATE ESTER TETRAAMMONIUM 95.00%
5MG
$ 502.81

Total 3 raw suppliers

Chemical Property of (1R,2S,4S,5S)-4-[2-IODO-6-(METHYLAMINO)-9H-PURIN-9-YL]-2-(PHOSPHONOOXY)BICYCLO[3.1.0]HEXANE-1-METHANOL DIHYDROGEN PHOSPHATE ESTER TETRAAMMONIUM SALT

Chemical Property:

PSA：221.73000
LogP:2.37950
Storage Temp.:Store at -20°C

Purity/Quality:

97% ^*data from raw suppliers

MRS 2500 tetraammonium salt ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses MRS 2500 tetraammonium salt is a highly potent and selective antagonist of the platelet P2Y1 receptor. It inhibits ADP-induced aggregation of human platelets.

Technology Process of (1R,2S,4S,5S)-4-[2-IODO-6-(METHYLAMINO)-9H-PURIN-9-YL]-2-(PHOSPHONOOXY)BICYCLO[3.1.0]HEXANE-1-METHANOL DIHYDROGEN PHOSPHATE ESTER TETRAAMMONIUM SALT

There total 18 articles about (1R,2S,4S,5S)-4-[2-IODO-6-(METHYLAMINO)-9H-PURIN-9-YL]-2-(PHOSPHONOOXY)BICYCLO[3.1.0]HEXANE-1-METHANOL DIHYDROGEN PHOSPHATE ESTER TETRAAMMONIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 74-89-5
methylamine

: (1'R,2'S,4'S,5'S)-4-(6-chloro-2-iodo-9H-purin-9-yl)-1-[(phosphato)-methyl]-2-(phosphato)bicyclo[3.1.0]hexane tetrakis ammonium salt

: 779323-43-2
MRS2500

Guidance literature:: In water; at 20 ℃; for 2h;
DOI:10.1016/j.bcp.2004.06.026

Reference yield:

: 259659-49-9
(1S,2R,4S,5R)-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl]bicyclo[3.1.0]hexan-2-ol

: 779323-43-2
MRS2500

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / 20 °C

2: 76 mg / H₂ / Pd/C / methanol / 4 h / 20 °C

3: 1H-tetrazole / tetrahydrofuran / 1 h / 20 °C

4: 71 mg / m-CPBA / tetrahydrofuran / 0.5 h / -78 - 20 °C

5: 79 percent / potassium carbonate; methanol / 2 h / 20 °C

6: 57 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 72 h / 20 °C

7: 47 percent / tetrahydrofuran / 3 h

8: trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

With 1H-tetrazole; methanol; dmap; hydrogen; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; 6: Mitsunobu reaction;
DOI:10.1021/jm030127+

Reference yield:

: Acetic acid (1S,2R,4S,5R)-4-benzyloxy-5-benzyloxymethyl-bicyclo[3.1.0]hex-2-yl ester

: 779323-43-2
MRS2500

Guidance literature:: Multi-step reaction with 7 steps

1: 76 mg / H₂ / Pd/C / methanol / 4 h / 20 °C

2: 1H-tetrazole / tetrahydrofuran / 1 h / 20 °C

3: 71 mg / m-CPBA / tetrahydrofuran / 0.5 h / -78 - 20 °C

4: 79 percent / potassium carbonate; methanol / 2 h / 20 °C

5: 57 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 72 h / 20 °C

6: 47 percent / tetrahydrofuran / 3 h

7: trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

With 1H-tetrazole; methanol; hydrogen; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; 5: Mitsunobu reaction;
DOI:10.1021/jm030127+