[2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-carbamic acid methyl ester

Base Information

Chemical Name:[2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-carbamic acid methyl ester
CAS No.:1365990-73-3
Molecular Formula:C₁₄H₈Cl₂FN₃O₂S
Molecular Weight:372.207
Hs Code.:

Synonyms:[2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-carbamic acid methyl ester

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Chemical Property of [2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-carbamic acid methyl ester

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Technology Process of [2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-carbamic acid methyl ester

There total 11 articles about [2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1365992-63-7
2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-ylamine

: 79-22-1
methyl chloroformate

: 1365990-73-3
[2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-carbamic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 - 50 ℃; for 22.5h;

Reference yield:

: 79455-63-3
2-chloro-6-fluorobenzoyl chloride

: 1365990-73-3
[2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: pyridine / 3.17 h / 0 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: sodium hydroxide; methanol / 5 h / 20 - 80 °C

3.1: thionyl chloride / 18 h / 100 °C

4.1: thiourea; pyridine / isopropyl alcohol / 4 h / 85 °C / Inert atmosphere

4.2: 18 h / 85 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5.05 h / 0 - 20 °C / Inert atmosphere

6.1: trichlorophosphate / 18.75 h / 20 °C / Reflux

7.1: trimethylsilyl bromide / propiononitrile / 20 - 85 °C / Inert atmosphere

8.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 3 h / 70 °C / Inert atmosphere

9.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

10.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 22.5 h / 20 - 50 °C

With pyridine; methanol; potassium phosphate; thionyl chloride; trimethylsilyl bromide; N-ethyl-N,N-diisopropylamine; thiourea; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium hydroxide; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; toluene; propiononitrile;

Reference yield:

: 159783-22-9
3,5-difluoropyridin-4-ylamine

: 1365990-73-3
[2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: pyridine / 3.17 h / 0 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: sodium hydroxide; methanol / 5 h / 20 - 80 °C

3.1: thionyl chloride / 18 h / 100 °C

4.1: thiourea; pyridine / isopropyl alcohol / 4 h / 85 °C / Inert atmosphere

4.2: 18 h / 85 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5.05 h / 0 - 20 °C / Inert atmosphere

6.1: trichlorophosphate / 18.75 h / 20 °C / Reflux

7.1: trimethylsilyl bromide / propiononitrile / 20 - 85 °C / Inert atmosphere

8.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 3 h / 70 °C / Inert atmosphere

9.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

10.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 22.5 h / 20 - 50 °C

With pyridine; methanol; potassium phosphate; thionyl chloride; trimethylsilyl bromide; N-ethyl-N,N-diisopropylamine; thiourea; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium hydroxide; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; toluene; propiononitrile;