2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-ylamine

Base Information

Chemical Name:2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-ylamine
CAS No.:1365992-63-7
Molecular Formula:C₁₂H₆Cl₂FN₃S
Molecular Weight:314.17
Hs Code.:

Synonyms:2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-ylamine

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Chemical Property of 2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-ylamine

Chemical Property:

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Technology Process of 2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-ylamine

There total 10 articles about 2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365992-62-6
[2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-carbamic acid tert-butyl ester

: 1365992-63-7
2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-ylamine

Guidance literature:: [2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-yl]-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;

With ammonia; In methanol;

Reference yield:

: 79455-63-3
2-chloro-6-fluorobenzoyl chloride

: 1365992-63-7
2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-ylamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / 3.17 h / 0 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: thionyl chloride / 18 h / 100 °C

3.1: thiourea; pyridine / isopropyl alcohol / 4 h / 85 °C / Inert atmosphere

3.2: 18 h / 85 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5.05 h / 0 - 20 °C / Inert atmosphere

5.1: trichlorophosphate / 18.75 h / 20 °C / Reflux

6.1: trimethylsilyl bromide / propiononitrile / 20 - 85 °C / Inert atmosphere

7.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 3 h / 70 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

With pyridine; potassium phosphate; thionyl chloride; trimethylsilyl bromide; thiourea; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; water; isopropyl alcohol; toluene; propiononitrile;

Reference yield:

: 159783-22-9
3,5-difluoropyridin-4-ylamine

: 1365992-63-7
2-(2,6-dichlorophenyl)-7-fluorothiazolo[5,4-c]pyridin-4-ylamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / 3.17 h / 0 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: thionyl chloride / 18 h / 100 °C

3.1: thiourea; pyridine / isopropyl alcohol / 4 h / 85 °C / Inert atmosphere

3.2: 18 h / 85 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5.05 h / 0 - 20 °C / Inert atmosphere

5.1: trichlorophosphate / 18.75 h / 20 °C / Reflux

6.1: trimethylsilyl bromide / propiononitrile / 20 - 85 °C / Inert atmosphere

7.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 3 h / 70 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

With pyridine; potassium phosphate; thionyl chloride; trimethylsilyl bromide; thiourea; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; water; isopropyl alcohol; toluene; propiononitrile;