5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole

Base Information

Chemical Name:5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole
CAS No.:1488426-97-6
Molecular Formula:C₂₀H₁₉FN₄S
Molecular Weight:366.462
Hs Code.:

Synonyms:5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole

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Chemical Property of 5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole

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Technology Process of 5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole

There total 8 articles about 5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.76%

: 1488426-95-4
5-(5-fluoro-1-methyl-1H-indol-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol

: 75-26-3
isopropyl bromide

: 1488426-97-6
5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole

Guidance literature:: 5-(5-fluoro-1-methyl-1H-indol-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.005h;

isopropyl bromide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.ejmech.2013.08.018

Reference yield:

: 371-40-4
4-fluoroaniline

: 1488426-97-6
5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride; sodium nitrite; tin(ll) chloride / -5 - 20 °C

2.1: acetic acid / ethanol / 1 h / 80 °C

3.1: polyphosphoric acid / toluene / 5 h / 100 °C

4.1: sodium hydride / tetrahydrofuran / 0.67 h / 0 °C

5.1: hydrazine hydrate / ethanol / 0.75 h / 80 °C

6.1: ethanol / 3 h / 80 °C

7.1: potassium hydroxide / water / 2 h / 110 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 0.01 h / 20 °C

8.2: 20 °C

With hydrogenchloride; sodium hydride; potassium carbonate; hydrazine hydrate; acetic acid; tin(ll) chloride; potassium hydroxide; sodium nitrite; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2013.08.018

Reference yield:

: 371-14-2
4-fluorophenylhydrazine

: 1488426-97-6
5-fluoro-2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / ethanol / 1 h / 80 °C

2.1: polyphosphoric acid / toluene / 5 h / 100 °C

3.1: sodium hydride / tetrahydrofuran / 0.67 h / 0 °C

4.1: hydrazine hydrate / ethanol / 0.75 h / 80 °C

5.1: ethanol / 3 h / 80 °C

6.1: potassium hydroxide / water / 2 h / 110 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 0.01 h / 20 °C

7.2: 20 °C

With sodium hydride; potassium carbonate; hydrazine hydrate; acetic acid; potassium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2013.08.018