1-(3-chloropyridin-2-yl)-N-[4-cyano-2-methyl-6-(methylcarbamoyl)phenyl]-3-{[5-(trifluoromethyl)-1H-1,2,3,4-tetrazol-1-yl]methyl}-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:1-(3-chloropyridin-2-yl)-N-[4-cyano-2-methyl-6-(methylcarbamoyl)phenyl]-3-{[5-(trifluoromethyl)-1H-1,2,3,4-tetrazol-1-yl]methyl}-1H-pyrazole-5-carboxamide
CAS No.:1229656-17-0
Molecular Formula:C₂₂H₁₆ClF₃N₁₀O₂
Molecular Weight:544.883
Hs Code.:

1-(3-chloropyridin-2-yl)-N-[4-cyano-2-methyl-6-(methylcarbamoyl)phenyl]-3-{[5-(trifluoromethyl)-1H-1,2,3,4-tetrazol-1-yl]methyl}-1H-pyrazole-5-carboxamide

Synonyms:1-(3-chloropyridin-2-yl)-N-[4-cyano-2-methyl-6-(methylcarbamoyl)phenyl]-3-{[5-(trifluoromethyl)-1H-1,2,3,4-tetrazol-1-yl]methyl}-1H-pyrazole-5-carboxamide

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Chemical Property of 1-(3-chloropyridin-2-yl)-N-[4-cyano-2-methyl-6-(methylcarbamoyl)phenyl]-3-{[5-(trifluoromethyl)-1H-1,2,3,4-tetrazol-1-yl]methyl}-1H-pyrazole-5-carboxamide

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Technology Process of 1-(3-chloropyridin-2-yl)-N-[4-cyano-2-methyl-6-(methylcarbamoyl)phenyl]-3-{[5-(trifluoromethyl)-1H-1,2,3,4-tetrazol-1-yl]methyl}-1H-pyrazole-5-carboxamide

There total 4 articles about 1-(3-chloropyridin-2-yl)-N-[4-cyano-2-methyl-6-(methylcarbamoyl)phenyl]-3-{[5-(trifluoromethyl)-1H-1,2,3,4-tetrazol-1-yl]methyl}-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 890707-29-6
2-amino-3-methyl-5-cyanobenzoyl-N-methylamine

: 1247712-63-5
methyl 3-(chloromethyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylate

: sodium 5-(trifluoromethyl)tetrazol-2-ide

: 1229654-66-3
1-(3-chloro-2-pyridinyl)-N-[4-cyano-2-methyl-6-[(methylamino)carbonyl]phenyl]-3-[[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl]-1H-pyrazole-5-carboxamide

: 1229656-17-0
1-(3-chloropyridin-2-yl)-N-[4-cyano-2-methyl-6-(methylcarbamoyl)phenyl]-3-{[5-(trifluoromethyl)-1H-1,2,3,4-tetrazol-1-yl]methyl}-1H-pyrazole-5-carboxamide

Guidance literature:: methyl 3-(chloromethyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylate; sodium 5-(trifluoromethyl)tetrazol-2-ide; potassium iodide; In acetone; at 56 ℃; for 10h;

With water; sodium hydroxide; In toluene; at 40 ℃; for 6h;

2-amino-3-methyl-5-cyanobenzoyl-N-methylamine;

Reference yield:

: 891779-59-2
8-methyl-2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-carbonitrile

: 1247712-63-5
methyl 3-(chloromethyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylate

: sodium 5-(trifluoromethyl)tetrazol-2-ide

: 74-89-5
methylamine

: 1229654-66-3
1-(3-chloro-2-pyridinyl)-N-[4-cyano-2-methyl-6-[(methylamino)carbonyl]phenyl]-3-[[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl]-1H-pyrazole-5-carboxamide

: 1229656-17-0
1-(3-chloropyridin-2-yl)-N-[4-cyano-2-methyl-6-(methylcarbamoyl)phenyl]-3-{[5-(trifluoromethyl)-1H-1,2,3,4-tetrazol-1-yl]methyl}-1H-pyrazole-5-carboxamide

Guidance literature:: methyl 3-(chloromethyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylate; sodium 5-(trifluoromethyl)tetrazol-2-ide; With potassium iodide; In acetone; at 56 ℃; for 12h;

With water; sodium hydroxide; In methanol; at 20 ℃; for 3h;

8-methyl-2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-6-carbonitrile; methylamine; Overall yield = 52 g; Further stages;

Reference yield:

: 5-bromo-4-methoxy-1,1,1-trichloro-pent-3-en-2-one

: 890707-29-6
2-amino-3-methyl-5-cyanobenzoyl-N-methylamine

: 22841-92-5
(3-chloro-2-pyridyl)hydrazine

: sodium 5-(trifluoromethyl)tetrazol-2-ide

: 1229654-66-3
1-(3-chloro-2-pyridinyl)-N-[4-cyano-2-methyl-6-[(methylamino)carbonyl]phenyl]-3-[[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl]-1H-pyrazole-5-carboxamide

: 1229656-17-0
1-(3-chloropyridin-2-yl)-N-[4-cyano-2-methyl-6-(methylcarbamoyl)phenyl]-3-{[5-(trifluoromethyl)-1H-1,2,3,4-tetrazol-1-yl]methyl}-1H-pyrazole-5-carboxamide

Guidance literature:: 5-bromo-4-methoxy-1,1,1-trichloro-pent-3-en-2-one; sodium 5-(trifluoromethyl)tetrazol-2-ide; In acetonitrile; at 60 ℃; for 3h;

(3-chloro-2-pyridyl)hydrazine; In acetonitrile; at 25 ℃; for 2h;

2-amino-3-methyl-5-cyanobenzoyl-N-methylamine; Overall yield = 1.38 g; Further stages;