4-(4-{[4-cyano-1-(2-trimethylsilanylethoxymethyl)-1H-imidazole-2-carbonyl]amino}-3-cyclohex-1-enylphenyl)piperidine-1-carboxylic acid (2-hydroxyethyl)amide

Base Information

Chemical Name:4-(4-{[4-cyano-1-(2-trimethylsilanylethoxymethyl)-1H-imidazole-2-carbonyl]amino}-3-cyclohex-1-enylphenyl)piperidine-1-carboxylic acid (2-hydroxyethyl)amide
CAS No.:885693-16-3
Molecular Formula:C₃₁H₄₄N₆O₄Si
Molecular Weight:592.814
Hs Code.:

4-(4-{[4-cyano-1-(2-trimethylsilanylethoxymethyl)-1H-imidazole-2-carbonyl]amino}-3-cyclohex-1-enylphenyl)piperidine-1-carboxylic acid (2-hydroxyethyl)amide

Synonyms:4-(4-{[4-cyano-1-(2-trimethylsilanylethoxymethyl)-1H-imidazole-2-carbonyl]amino}-3-cyclohex-1-enylphenyl)piperidine-1-carboxylic acid (2-hydroxyethyl)amide

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Chemical Property of 4-(4-{[4-cyano-1-(2-trimethylsilanylethoxymethyl)-1H-imidazole-2-carbonyl]amino}-3-cyclohex-1-enylphenyl)piperidine-1-carboxylic acid (2-hydroxyethyl)amide

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Technology Process of 4-(4-{[4-cyano-1-(2-trimethylsilanylethoxymethyl)-1H-imidazole-2-carbonyl]amino}-3-cyclohex-1-enylphenyl)piperidine-1-carboxylic acid (2-hydroxyethyl)amide

There total 11 articles about 4-(4-{[4-cyano-1-(2-trimethylsilanylethoxymethyl)-1H-imidazole-2-carbonyl]amino}-3-cyclohex-1-enylphenyl)piperidine-1-carboxylic acid (2-hydroxyethyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 885693-15-2
4-cyano-1-(2-trimethylsilanylethoxymethyl)-1H-imidazole-2-carboxylic acid (2-cyclohex-1-enyl-4-piperidin-4-ylphenyl)amide trifluoroacetic acid salt

: 141-43-5
ethanolamine

: 885693-16-3
4-(4-{[4-cyano-1-(2-trimethylsilanylethoxymethyl)-1H-imidazole-2-carbonyl]amino}-3-cyclohex-1-enylphenyl)piperidine-1-carboxylic acid (2-hydroxyethyl)amide

Guidance literature:: 4-cyano-1-(2-trimethylsilanylethoxymethyl)-1H-imidazole-2-carboxylic acid (2-cyclohex-1-enyl-4-piperidin-4-ylphenyl)amide trifluoroacetic acid salt; bis(trichloromethyl) carbonate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - 20 ℃; for 0.5h;

ethanolamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 20h;

Reference yield: 83.0%

: C₃₀H₃₈Cl₃N₅O₄Si

: 141-43-5
ethanolamine

: 885693-16-3
4-(4-{[4-cyano-1-(2-trimethylsilanylethoxymethyl)-1H-imidazole-2-carbonyl]amino}-3-cyclohex-1-enylphenyl)piperidine-1-carboxylic acid (2-hydroxyethyl)amide

Guidance literature:: In tetrahydrofuran; dichloromethane; at 20 ℃; for 20h;

Reference yield: 83.0%

: 885693-15-2
4-cyano-1-(2-trimethylsilanylethoxymethyl)-1H-imidazole-2-carboxylic acid (2-cyclohex-1-enyl-4-piperidin-4-ylphenyl)amide trifluoroacetic acid salt

: 32315-10-9
bis(trichloromethyl) carbonate

: 141-43-5
ethanolamine

: 885693-16-3
4-(4-{[4-cyano-1-(2-trimethylsilanylethoxymethyl)-1H-imidazole-2-carbonyl]amino}-3-cyclohex-1-enylphenyl)piperidine-1-carboxylic acid (2-hydroxyethyl)amide

Guidance literature:: 4-cyano-1-(2-trimethylsilanylethoxymethyl)-1H-imidazole-2-carboxylic acid (2-cyclohex-1-enyl-4-piperidin-4-ylphenyl)amide trifluoroacetic acid salt; bis(trichloromethyl) carbonate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

ethanolamine; In tetrahydrofuran; dichloromethane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm200900q