Technology Process of (2S,3R)-N-((2-(Dimethylamino)ethyl)sulfanyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide
There total 12 articles about (2S,3R)-N-((2-(Dimethylamino)ethyl)sulfanyl)-N’-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
bis(N,N-dimethyl-2-aminoethyl)disulfide;
With
silver nitrate;
In
methanol;
at 24 ℃;
for 0.333333h;
(2R,3S)-N-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3- trifluoropropyl)succinamide;
With
triethylamine;
at 20 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide
2.1: trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere
3.1: ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / Inert atmosphere
4.1: silver nitrate / methanol / 0.33 h / 24 °C
4.2: 24 h / 20 °C
With
ammonium chloride; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 20 - 25 °C / Autoclave; Inert atmosphere
2.1: N,N-dimethyl-formamide / 20 - 25 °C / Inert atmosphere
2.2: 20 - 25 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere
4.1: ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / Inert atmosphere
5.1: silver nitrate / methanol / 0.33 h / 24 °C
5.2: 24 h / 20 °C
With
palladium 10% on activated carbon; hydrogen; ammonium chloride; benzotriazol-1-ol; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
