{4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethylsulfanyl]-2,6-difluorophenoxy}acetic acid ethyl ester

Base Information

Chemical Name:{4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethylsulfanyl]-2,6-difluorophenoxy}acetic acid ethyl ester
CAS No.:141286-84-2
Molecular Formula:C₂₀H₁₇F₂NO₅S
Molecular Weight:421.421
Hs Code.:

Synonyms:{4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethylsulfanyl]-2,6-difluorophenoxy}acetic acid ethyl ester

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Chemical Property of {4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethylsulfanyl]-2,6-difluorophenoxy}acetic acid ethyl ester

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Technology Process of {4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethylsulfanyl]-2,6-difluorophenoxy}acetic acid ethyl ester

There total 6 articles about {4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethylsulfanyl]-2,6-difluorophenoxy}acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 105-36-2
ethyl bromoacetate

: 169298-43-5
N-<2-(3,5-difluoro-4-hydroxyphenylthio)ethyl>phthalimide

: 141286-84-2
{4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethylsulfanyl]-2,6-difluorophenoxy}acetic acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃;

Reference yield: 97.0%

: 539-74-2
Ethyl 3-bromopropionate

: 169298-43-5
N-<2-(3,5-difluoro-4-hydroxyphenylthio)ethyl>phthalimide

: 141286-84-2
{4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethylsulfanyl]-2,6-difluorophenoxy}acetic acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃;

Reference yield:

: 28177-48-2
2,6-difluorophenol

: 141286-84-2
{4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethylsulfanyl]-2,6-difluorophenoxy}acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: chlorosulfonic acid / CH₂Cl₂ / 2 h / Heating

2: Zn, 25percent H₂SO₄ / 4 h / Heating

3: 67 percent / K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

4: 90.2 percent / K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

With chlorosulfonic acid; sulfuric acid; potassium carbonate; zinc; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(96)88250-X