(S)-2-{[(benzyloxy)carbonyl]amino}methyl-3-[4-(tert-butoxy)phenyl]propanoic acid

Base Information

Chemical Name:(S)-2-{[(benzyloxy)carbonyl]amino}methyl-3-[4-(tert-butoxy)phenyl]propanoic acid
CAS No.:637337-77-0
Molecular Formula:C₂₂H₂₇NO₅
Molecular Weight:385.46
Hs Code.:

Synonyms:(S)-2-{[(benzyloxy)carbonyl]amino}methyl-3-[4-(tert-butoxy)phenyl]propanoic acid

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Chemical Property of (S)-2-{[(benzyloxy)carbonyl]amino}methyl-3-[4-(tert-butoxy)phenyl]propanoic acid

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Technology Process of (S)-2-{[(benzyloxy)carbonyl]amino}methyl-3-[4-(tert-butoxy)phenyl]propanoic acid

There total 7 articles about (S)-2-{[(benzyloxy)carbonyl]amino}methyl-3-[4-(tert-butoxy)phenyl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 671233-54-8
(R)-3-[(S)-2-{[(benzyloxy)carbonyl]amino}methyl-3-[4-(tert-butoxy)phenyl]-1-oxopropyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

: 637337-77-0
(S)-2-{[(benzyloxy)carbonyl]amino}methyl-3-[4-(tert-butoxy)phenyl]propanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 25 ℃; for 2.5h;
DOI:10.1002/hlca.200390337

Reference yield:

: 501-97-3
4-hydroxyphenylpropionic acid

: 637337-77-0
(S)-2-{[(benzyloxy)carbonyl]amino}methyl-3-[4-(tert-butoxy)phenyl]propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 77 percent / 1H-imidazole / dimethylformamide / 5 h / 25 °C

2.1: pivaloyl chloride; Et₃N / tetrahydrofuran / 1.5 h / -30 °C

2.2: 79 percent / LiCl / tetrahydrofuran / -30 - 25 °C

3.1: 62 percent / TiCl₄; Et₃N / CH₂Cl₂ / 4 h / 0 °C

4.1: 93 percent / TBAF / tetrahydrofuran / 4 h / 25 °C

5.1: 73 percent / CF₃SO₃H / CH₂Cl₂ / 5 h / -30 °C

6.1: 94 percent / aq. NaOH / methanol; tetrahydrofuran / 2.5 h / 25 °C

With 1H-imidazole; sodium hydroxide; trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; pivaloyl chloride; titanium tetrachloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390337

Reference yield:

: 94471-35-9
benzyl N-(methoxymethyl) carbamate

: 637337-77-0
(S)-2-{[(benzyloxy)carbonyl]amino}methyl-3-[4-(tert-butoxy)phenyl]propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / TiCl₄; Et₃N / CH₂Cl₂ / 4 h / 0 °C

2: 93 percent / TBAF / tetrahydrofuran / 4 h / 25 °C

3: 73 percent / CF₃SO₃H / CH₂Cl₂ / 5 h / -30 °C

4: 94 percent / aq. NaOH / methanol; tetrahydrofuran / 2.5 h / 25 °C

With sodium hydroxide; trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; titanium tetrachloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/hlca.200390337