Carbamic acid, [(2S)-2-[[4-(1,1-dimethylethoxy)phenyl]methyl]-3-[(4R)-4-(1-methylethyl)- 2-oxo-5,5-diphenyl-3-oxazolidinyl]-3-oxopropyl]-, phenylmethyl ester

Base Information

Chemical Name:Carbamic acid, [(2S)-2-[[4-(1,1-dimethylethoxy)phenyl]methyl]-3-[(4R)-4-(1-methylethyl)- 2-oxo-5,5-diphenyl-3-oxazolidinyl]-3-oxopropyl]-, phenylmethyl ester
CAS No.:671233-54-8
Molecular Formula:C40H44N2O6
Molecular Weight:648.799
Hs Code.:

Carbamic acid,
[(2S)-2-[[4-(1,1-dimethylethoxy)phenyl]methyl]-3-[(4R)-4-(1-methylethyl)-
2-oxo-5,5-diphenyl-3-oxazolidinyl]-3-oxopropyl]-, phenylmethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [(2S)-2-[[4-(1,1-dimethylethoxy)phenyl]methyl]-3-[(4R)-4-(1-methylethyl)- 2-oxo-5,5-diphenyl-3-oxazolidinyl]-3-oxopropyl]-, phenylmethyl ester

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Technology Process of Carbamic acid, [(2S)-2-[[4-(1,1-dimethylethoxy)phenyl]methyl]-3-[(4R)-4-(1-methylethyl)- 2-oxo-5,5-diphenyl-3-oxazolidinyl]-3-oxopropyl]-, phenylmethyl ester

There total 6 articles about Carbamic acid, [(2S)-2-[[4-(1,1-dimethylethoxy)phenyl]methyl]-3-[(4R)-4-(1-methylethyl)- 2-oxo-5,5-diphenyl-3-oxazolidinyl]-3-oxopropyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 115-11-7,15220-85-6
isobutene

: 671233-53-7
(R)-3-[(S)-2-{[(benzyloxy)carbonyl]amino}methyl-3-(4-hydroxyphenyl)-1-oxopropyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

: 671233-54-8
(R)-3-[(S)-2-{[(benzyloxy)carbonyl]amino}methyl-3-[4-(tert-butoxy)phenyl]-1-oxopropyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; at -30 ℃; for 5h;
DOI:10.1002/hlca.200390337

Reference yield:

: 501-97-3
4-hydroxyphenylpropionic acid

: 671233-54-8
(R)-3-[(S)-2-{[(benzyloxy)carbonyl]amino}methyl-3-[4-(tert-butoxy)phenyl]-1-oxopropyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 77 percent / 1H-imidazole / dimethylformamide / 5 h / 25 °C

2.1: pivaloyl chloride; Et₃N / tetrahydrofuran / 1.5 h / -30 °C

2.2: 79 percent / LiCl / tetrahydrofuran / -30 - 25 °C

3.1: 62 percent / TiCl₄; Et₃N / CH₂Cl₂ / 4 h / 0 °C

4.1: 93 percent / TBAF / tetrahydrofuran / 4 h / 25 °C

5.1: 73 percent / CF₃SO₃H / CH₂Cl₂ / 5 h / -30 °C

With 1H-imidazole; trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; pivaloyl chloride; titanium tetrachloride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390337

Reference yield:

: 94471-35-9
benzyl N-(methoxymethyl) carbamate

: 671233-54-8
(R)-3-[(S)-2-{[(benzyloxy)carbonyl]amino}methyl-3-[4-(tert-butoxy)phenyl]-1-oxopropyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / TiCl₄; Et₃N / CH₂Cl₂ / 4 h / 0 °C

2: 93 percent / TBAF / tetrahydrofuran / 4 h / 25 °C

3: 73 percent / CF₃SO₃H / CH₂Cl₂ / 5 h / -30 °C

With trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; titanium tetrachloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/hlca.200390337