2,2,2-Trichloro-acetimidic acid (3S,4S)-5-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-4-methyl-2-methylene-pentyl ester

Base Information

Chemical Name:2,2,2-Trichloro-acetimidic acid (3S,4S)-5-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-4-methyl-2-methylene-pentyl ester
CAS No.:216449-81-9
Molecular Formula:C₂₅H₃₂Cl₃NO₃Si
Molecular Weight:528.978
Hs Code.:

Synonyms:2,2,2-Trichloro-acetimidic acid (3S,4S)-5-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-4-methyl-2-methylene-pentyl ester

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Chemical Property of 2,2,2-Trichloro-acetimidic acid (3S,4S)-5-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-4-methyl-2-methylene-pentyl ester

Chemical Property:

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Technology Process of 2,2,2-Trichloro-acetimidic acid (3S,4S)-5-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-4-methyl-2-methylene-pentyl ester

There total 2 articles about 2,2,2-Trichloro-acetimidic acid (3S,4S)-5-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-4-methyl-2-methylene-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 545-06-2
trichloroacetonitrile

: 216449-79-5
(3S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-methylene-pentane-1,3-diol

: 216449-81-9
2,2,2-Trichloro-acetimidic acid (3S,4S)-5-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-4-methyl-2-methylene-pentyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In various solvent(s); at -78 ℃;
DOI:10.1039/a804954h

Reference yield:

: ((2S,3S)-3-((S)-1-((1,1-dimethylethyl)diphenylsilyloxy)propan-2-yl)-2-methyloxiran-2-yl)methanol

: 216449-81-9
2,2,2-Trichloro-acetimidic acid (3S,4S)-5-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-4-methyl-2-methylene-pentyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / LDA / tetrahydrofuran / 0 - 24 °C

2: DBU / various solvent(s) / -78 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1039/a804954h

Reference yield:

: 216449-81-9
2,2,2-Trichloro-acetimidic acid (3S,4S)-5-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-4-methyl-2-methylene-pentyl ester

: 216449-87-5
1-{4-[(1S,2S)-3-(tert-Butyl-diphenyl-silanyloxy)-1-methoxymethoxy-2-methyl-propyl]-2-trichloromethyl-4,5-dihydro-oxazol-4-ylmethoxy}-2,2,6,6-tetramethyl-piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Hg(O₂CCF₃)2, K₂CO₃, KBr, H₂O, 2.) LiBH₄ / 1.) THF, 0 deg C, 2.) THF, 24 deg C

2: (i-Pr)2NEt / CH₂Cl₂ / 0 - 24 °C

With lithium borohydride; water; mercury(II) trifluoroacetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium bromide; In dichloromethane;
DOI:10.1039/a804954h