(1S,2S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-1-[4-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-2-trichloromethyl-4,5-dihydro-oxazol-4-yl]-propan-1-ol

Base Information

Chemical Name:(1S,2S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-1-[4-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-2-trichloromethyl-4,5-dihydro-oxazol-4-yl]-propan-1-ol
CAS No.:216449-85-3
Molecular Formula:C₃₄H₄₉Cl₃N₂O₄Si
Molecular Weight:684.219
Hs Code.:

(1S,2S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-1-[4-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-2-trichloromethyl-4,5-dihydro-oxazol-4-yl]-propan-1-ol

Synonyms:(1S,2S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-1-[4-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-2-trichloromethyl-4,5-dihydro-oxazol-4-yl]-propan-1-ol

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Chemical Property of (1S,2S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-1-[4-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-2-trichloromethyl-4,5-dihydro-oxazol-4-yl]-propan-1-ol

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Technology Process of (1S,2S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-1-[4-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-2-trichloromethyl-4,5-dihydro-oxazol-4-yl]-propan-1-ol

There total 3 articles about (1S,2S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-1-[4-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-2-trichloromethyl-4,5-dihydro-oxazol-4-yl]-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ((2S,3S)-3-((S)-1-((1,1-dimethylethyl)diphenylsilyloxy)propan-2-yl)-2-methyloxiran-2-yl)methanol

: 216449-85-3
(1S,2S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-1-[4-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-2-trichloromethyl-4,5-dihydro-oxazol-4-yl]-propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / LDA / tetrahydrofuran / 0 - 24 °C

2: DBU / various solvent(s) / -78 °C

3: 1.) Hg(O₂CCF₃)2, K₂CO₃, KBr, H₂O, 2.) LiBH₄ / 1.) THF, 0 deg C, 2.) THF, 24 deg C

With lithium borohydride; water; mercury(II) trifluoroacetate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium bromide; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1039/a804954h

Reference yield:

: 216449-79-5
(3S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-methylene-pentane-1,3-diol

: 216449-85-3
(1S,2S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-1-[4-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-2-trichloromethyl-4,5-dihydro-oxazol-4-yl]-propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: DBU / various solvent(s) / -78 °C

2: 1.) Hg(O₂CCF₃)2, K₂CO₃, KBr, H₂O, 2.) LiBH₄ / 1.) THF, 0 deg C, 2.) THF, 24 deg C

With lithium borohydride; water; mercury(II) trifluoroacetate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium bromide; In various solvent(s);
DOI:10.1039/a804954h

Reference yield:

: 2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

: 216449-81-9
2,2,2-Trichloro-acetimidic acid (3S,4S)-5-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-4-methyl-2-methylene-pentyl ester

: 216449-85-3
(1S,2S)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-1-[4-(2,2,6,6-tetramethyl-piperidin-1-yloxymethyl)-2-trichloromethyl-4,5-dihydro-oxazol-4-yl]-propan-1-ol

Guidance literature:: With lithium borohydride; water; mercury(II) trifluoroacetate; potassium carbonate; potassium bromide; Yield given. Multistep reaction; 1.) THF, 0 deg C, 2.) THF, 24 deg C;
DOI:10.1039/a804954h