(R)-2-{2-fluoro-4-[(pyridine-2-carbonyl)amino]phenyl}pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(R)-2-{2-fluoro-4-[(pyridine-2-carbonyl)amino]phenyl}pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:1034497-96-5
Molecular Formula:C₂₁H₂₄FN₃O₃
Molecular Weight:385.438
Hs Code.:

Synonyms:(R)-2-{2-fluoro-4-[(pyridine-2-carbonyl)amino]phenyl}pyrrolidine-1-carboxylic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-{2-fluoro-4-[(pyridine-2-carbonyl)amino]phenyl}pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (R)-2-{2-fluoro-4-[(pyridine-2-carbonyl)amino]phenyl}pyrrolidine-1-carboxylic acid tert-butyl ester

There total 1 articles about (R)-2-{2-fluoro-4-[(pyridine-2-carbonyl)amino]phenyl}pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-98-6
2-Picolinic acid

: 656-65-5
3-fluoro-4-bromophenylamine

: 86953-79-9
tert-butyl pyrrolidine-1-carboxylate

: 1034497-96-5
(R)-2-{2-fluoro-4-[(pyridine-2-carbonyl)amino]phenyl}pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multistep reaction.;
DOI:10.1021/jo8006804

Reference yield:

: 1034497-96-5
(R)-2-{2-fluoro-4-[(pyridine-2-carbonyl)amino]phenyl}pyrrolidine-1-carboxylic acid tert-butyl ester

: 108-24-7
acetic anhydride

: 1034498-00-4
pyridine-2-carboxylic acid [4-((R)-1-acetylpyrrolidin-2-yl)-3-fluorophenyl]amide

Guidance literature:: (R)-2-{2-fluoro-4-[(pyridine-2-carbonyl)amino]phenyl}pyrrolidine-1-carboxylic acid tert-butyl ester; With hydrogenchloride; at 5 - 20 ℃; for 4h;

acetic anhydride; With sodium hydroxide; In dichloromethane; at 0 - 20 ℃; pH=14; Further stages.;
DOI:10.1021/jo8006804