(S)-(3-neopentylpyridin-2-yl)(4-(trifluoromethyl)phenyl)-methanamine hydrochloride

Base Information

Chemical Name:(S)-(3-neopentylpyridin-2-yl)(4-(trifluoromethyl)phenyl)-methanamine hydrochloride
CAS No.:1416800-57-1
Molecular Formula:C₁₈H₂₁F₃N₂*ClH
Molecular Weight:358.834
Hs Code.:

Synonyms:(S)-(3-neopentylpyridin-2-yl)(4-(trifluoromethyl)phenyl)-methanamine hydrochloride

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Chemical Property of (S)-(3-neopentylpyridin-2-yl)(4-(trifluoromethyl)phenyl)-methanamine hydrochloride

Chemical Property:

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Technology Process of (S)-(3-neopentylpyridin-2-yl)(4-(trifluoromethyl)phenyl)-methanamine hydrochloride

There total 7 articles about (S)-(3-neopentylpyridin-2-yl)(4-(trifluoromethyl)phenyl)-methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 405174-97-2
3-bromopicolinaldehyde

: 1416800-57-1
(S)-(3-neopentylpyridin-2-yl)(4-(trifluoromethyl)phenyl)-methanamine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(II) sulfate / dichloromethane / 20 °C

2.1: magnesium / tetrahydrofuran / 4 h

2.2: 1 h / -78 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane; ethanol / 2 h / 0 °C

3.2: 20 °C

4.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / 135 °C / Microwave irradiation

4.2: 20 °C

With hydrogenchloride; copper(II) sulfate; magnesium; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 38749-79-0
3-bromo-2-picoline

: 1416800-57-1
(S)-(3-neopentylpyridin-2-yl)(4-(trifluoromethyl)phenyl)-methanamine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 30 h / Reflux

2.1: morpholine / 1 h / 60 °C

2.2: pH 4

3.1: copper(II) sulfate / dichloromethane / 20 °C

4.1: magnesium / tetrahydrofuran / 4 h

4.2: 1 h / -78 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane; ethanol / 2 h / 0 °C

5.2: 20 °C

6.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / 135 °C / Microwave irradiation

6.2: 20 °C

With morpholine; hydrogenchloride; N-Bromosuccinimide; copper(II) sulfate; magnesium; dibenzoyl peroxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; ethanol; dichloromethane;

Reference yield:

: 1416800-52-6
(S)-tert-butyl((3-bromopyridin-2-yl)(4-(trifluoromethyl)phenyl)methyl)carbamate

: 1416800-57-1
(S)-(3-neopentylpyridin-2-yl)(4-(trifluoromethyl)phenyl)-methanamine hydrochloride

Guidance literature:: (S)-tert-butyl((3-bromopyridin-2-yl)(4-(trifluoromethyl)phenyl)methyl)carbamate; With neopentylzinc(II) bromide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; at 135 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; In 1,4-dioxane; dichloromethane;