957110-22-4Relevant academic research and scientific papers
An improved high yield total synthesis and cytotoxicity study of the marine alkaloid neoamphimedine: An ATP-competitive inhibitor of topoisomerase IIα and potent anticancer agent
Li, Linfeng,Abraham, Adedoyin D.,Zhou, Qiong,Ali, Hadi,O'Brien, Jeremy V.,Hamill, Brayden D.,Arcaroli, John J.,Messersmith, Wells A.,LaBarbera, Daniel V.
, p. 4833 - 4850 (2015/01/08)
Recently, we characterized neoamphimedine (neo) as an ATP-competitive inhibitor of the ATPase domain of human Topoisomerase IIα. Thus far, neo is the only pyridoacridine with this mechanism of action. One limiting factor in the development of neo as a the
The total synthesis of neoamphimedine
LaBarbera, Daniel V.,Bugni, Tim S.,Ireland, Chris M.
, p. 8501 - 8505 (2008/02/13)
(Chemical Equation Presented) Neoamphimedine, a pyridoacridine alkaloid from Xestospongia sp., is a potent antitumor agent both in vitro and in vivo. Neoamphimedine can efficiently induce topoisomerase II mediated catenation of plasmid DNA in vitro and is
