3-fluoro-5-(4-methoxybenzyloxy)-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)azepane

Base Information

Chemical Name:3-fluoro-5-(4-methoxybenzyloxy)-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)azepane
CAS No.:1428573-74-3
Molecular Formula:C₁₈H₂₃FN₄O₄
Molecular Weight:378.403
Hs Code.:

Synonyms:3-fluoro-5-(4-methoxybenzyloxy)-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)azepane

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Chemical Property of 3-fluoro-5-(4-methoxybenzyloxy)-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)azepane

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Technology Process of 3-fluoro-5-(4-methoxybenzyloxy)-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)azepane

There total 5 articles about 3-fluoro-5-(4-methoxybenzyloxy)-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)azepane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 42098-25-9
5-chloro-1-methyl-4-nitro-1H-pyrazole

: 1428573-71-0
tert butyl 3-fluoro-5-(4-methoxybenzyloxy)azepane-1-carboxylate

: 1428573-74-3
3-fluoro-5-(4-methoxybenzyloxy)-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)azepane

Guidance literature:: tert butyl 3-fluoro-5-(4-methoxybenzyloxy)azepane-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; methanol; dimethyl sulfoxide; at 20 ℃; for 16h;

5-chloro-1-methyl-4-nitro-1H-pyrazole; With potassium fluoride; In dimethyl sulfoxide; at 65 ℃; for 16h;

Reference yield:

: 882529-68-2
(Z)-tert-butyl 3-oxo-2,3,6,7-tetrahydro-1H-azepine-1-carboxylate

: 1428573-74-3
3-fluoro-5-(4-methoxybenzyloxy)-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)azepane

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 23 h / 60 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; water / 1.5 h

3.1: sodium hydrogencarbonate; (bis-(2-methoxyethyl)amino)sulfur trufluoride / tetrahydrofuran; dichloromethane; water / 18 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane; methanol; dimethyl sulfoxide / 16 h / 20 °C

4.2: 16 h / 65 °C

With hydrogenchloride; sodium tetrahydroborate; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 1428573-74-3
3-fluoro-5-(4-methoxybenzyloxy)-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)azepane

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 23 h / 60 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; water / 1.5 h

3.1: sodium hydrogencarbonate; (bis-(2-methoxyethyl)amino)sulfur trufluoride / tetrahydrofuran; dichloromethane; water / 18 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane; methanol; dimethyl sulfoxide / 16 h / 20 °C

4.2: 16 h / 65 °C

With hydrogenchloride; sodium tetrahydroborate; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;