3-[3-chloro-4-(1-hydroxyethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Base Information

Chemical Name:3-[3-chloro-4-(1-hydroxyethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole
CAS No.:950482-80-1
Molecular Formula:C₁₈H₁₃Cl₃F₃NO₂
Molecular Weight:438.661
Hs Code.:

Synonyms:3-[3-chloro-4-(1-hydroxyethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

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Chemical Property of 3-[3-chloro-4-(1-hydroxyethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

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Technology Process of 3-[3-chloro-4-(1-hydroxyethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

There total 9 articles about 3-[3-chloro-4-(1-hydroxyethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 950482-80-1
3-[3-chloro-4-(1-hydroxyethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 3 h / Heating / reflux

2.1: N-chloro-succinimide / 1,2-dimethoxyethane / 2 h / 70 °C

2.2: 20 h / 20 °C

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / 3 h / 70 °C

4.1: acetic acid / 2 h / 120 °C

4.2: 20 °C

5.1: sodium hydroxide; ethanol; water / 1 h / 100 °C

6.1: pyridinium chlorochromate / dichloromethane / 20 h / 20 °C

7.1: tetrahydrofuran; diethyl ether / 0.5 h / 20 °C / Heating / reflux

7.2: 0 °C

With sodium hydroxide; N-chloro-succinimide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ethanol; water; potassium carbonate; acetic acid; pyridinium chlorochromate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane;

Reference yield:

: 930110-27-3
2-chloro-4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-benzaldehyde

: 75-16-1
methylmagnesium bromide

: 950482-80-1
3-[3-chloro-4-(1-hydroxyethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Guidance literature:: 2-chloro-4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-benzaldehyde; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 0.5h; Heating / reflux;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; at 0 ℃;

Reference yield:

: 930110-22-8
3-[3-chloro-4-(hydroxymethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

: 950482-80-1
3-[3-chloro-4-(1-hydroxyethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridinium chlorochromate / dichloromethane / 20 h / 20 °C

2.1: tetrahydrofuran; diethyl ether / 0.5 h / 20 °C / Heating / reflux

2.2: 0 °C

With pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; dichloromethane;