1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-carboxylic acid amide

Base Information

Chemical Name:1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-carboxylic acid amide
CAS No.:1268675-70-2
Molecular Formula:C₂₅H₂₁Cl₂N₃O
Molecular Weight:450.367
Hs Code.:

Synonyms:1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-carboxylic acid amide

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Chemical Property of 1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-carboxylic acid amide

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Technology Process of 1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-carboxylic acid amide

There total 8 articles about 1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268675-71-3
1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-carboxylic acid

: 1268675-70-2
1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-carboxylic acid amide

Guidance literature:: 1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-carboxylic acid; With pyridine; di-tert-butyl dicarbonate; In 1,4-dioxane; at 20 ℃; for 0.25h;

With ammonium bicarbonate; In 1,4-dioxane; at 40 ℃; for 20h;

Reference yield:

: 1268682-32-1
N-(5-chloro-2-methyl-phenyl)-3,4-dimethyl-benzamidine

: 1268675-70-2
1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / water; tetrahydrofuran / 12 h / 20 °C

2.1: toluene-4-sulfonic acid / toluene / 12 h / 60 °C

3.1: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C

4.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 6 h / 85 °C / Inert atmosphere

5.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 4.5 h / 20 - 60 °C

6.1: pyridine; di-tert-butyl dicarbonate / 1,4-dioxane / 0.25 h / 20 °C

6.2: 20 h / 40 °C

With pyridine; potassium phosphate; N-Bromosuccinimide; lithium hydroxide monohydrate; di-tert-butyl dicarbonate; water; sodium hydrogencarbonate; toluene-4-sulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; toluene; acetonitrile;

Reference yield:

: 1268682-30-9
1-(5-chloro-2-methyl-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-carboxylic acid ethyl ester

: 1268675-70-2
1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C

2.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 6 h / 85 °C / Inert atmosphere

3.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 4.5 h / 20 - 60 °C

4.1: pyridine; di-tert-butyl dicarbonate / 1,4-dioxane / 0.25 h / 20 °C

4.2: 20 h / 40 °C

With pyridine; potassium phosphate; N-Bromosuccinimide; lithium hydroxide monohydrate; di-tert-butyl dicarbonate; water; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; acetonitrile;