1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-nitrile

Base Information

Chemical Name:1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-nitrile
CAS No.:1268675-69-9
Molecular Formula:C₂₅H₁₉Cl₂N₃
Molecular Weight:432.352
Hs Code.:

Synonyms:1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-nitrile

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Chemical Property of 1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-nitrile

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Technology Process of 1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-nitrile

There total 9 articles about 1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-nitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268675-70-2
1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-carboxylic acid amide

: 1268675-69-9
1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-nitrile

Guidance literature:: With trifluoromethylsulfonic anhydride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.25h;

Reference yield:

: 1268682-32-1
N-(5-chloro-2-methyl-phenyl)-3,4-dimethyl-benzamidine

: 1268675-69-9
1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-nitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / water; tetrahydrofuran / 12 h / 20 °C

2.1: toluene-4-sulfonic acid / toluene / 12 h / 60 °C

3.1: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C

4.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 6 h / 85 °C / Inert atmosphere

5.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 4.5 h / 20 - 60 °C

6.1: pyridine; di-tert-butyl dicarbonate / 1,4-dioxane / 0.25 h / 20 °C

6.2: 20 h / 40 °C

7.1: trifluoromethylsulfonic anhydride; triethylamine / dichloromethane / 0.25 h / 0 - 20 °C

With pyridine; potassium phosphate; N-Bromosuccinimide; lithium hydroxide monohydrate; trifluoromethylsulfonic anhydride; di-tert-butyl dicarbonate; water; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1268682-30-9
1-(5-chloro-2-methyl-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-carboxylic acid ethyl ester

: 1268675-69-9
1-(5-chloro-2-methyl-phenyl)-5-(3-chloro-phenyl)-2-(3,4-dimethyl-phenyl)-1H-imidazole-4-nitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / acetonitrile / 16 h / 20 °C

2.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 6 h / 85 °C / Inert atmosphere

3.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 4.5 h / 20 - 60 °C

4.1: pyridine; di-tert-butyl dicarbonate / 1,4-dioxane / 0.25 h / 20 °C

4.2: 20 h / 40 °C

5.1: trifluoromethylsulfonic anhydride; triethylamine / dichloromethane / 0.25 h / 0 - 20 °C

With pyridine; potassium phosphate; N-Bromosuccinimide; lithium hydroxide monohydrate; trifluoromethylsulfonic anhydride; di-tert-butyl dicarbonate; water; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; acetonitrile;