(2S,4R)-2-trifluoromethyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine

Base Information

Chemical Name:(2S,4R)-2-trifluoromethyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine
CAS No.:904296-09-9
Molecular Formula:C₂₀H₂₀F₃NO₂
Molecular Weight:363.38
Hs Code.:

Synonyms:(2S,4R)-2-trifluoromethyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R)-2-trifluoromethyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine

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Technology Process of (2S,4R)-2-trifluoromethyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine

There total 2 articles about (2S,4R)-2-trifluoromethyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 904296-01-1
(2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine

: 100-39-0
benzyl bromide

: 904296-09-9
(2S,4R)-2-trifluoromethyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine

Guidance literature:: (2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.5h; Inert atmosphere;

benzyl bromide; With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -78 ℃; for 2h; Reagent/catalyst; Solvent; optical yield given as %de; diastereoselective reaction; Reactivity;
DOI:10.1002/chem.200701604

Reference yield: 63.0%

: 904296-01-1
(2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine

: 100-39-0
benzyl bromide

: 904296-09-9
(2S,4R)-2-trifluoromethyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine

: 1220352-21-5
(2S,4R)-2-trifluoromethyl-3-[(R)-2-hydroxypropanoyl]-4-phenyl-1,3-oxazolidine

: 1220352-23-7
(2S,4R)-2-trifluoromethyl-3-[(R)-2-hydroperoxypropanoyl]-4-phenyl-1,3-oxazolidine

Guidance literature:: (2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine; With potassium hexamethylsilazane;

benzyl bromide; With oxygen; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/ol100211s

Reference yield: 97.0%

: 904296-09-9
(2S,4R)-2-trifluoromethyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine

: 1009-67-2,5628-72-8,14367-54-5,14367-67-0
2-methyl-3-phenylpropionic acid

: 203176-56-1
(2S,4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

Guidance literature:: (2S,4R)-2-trifluoromethyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine; With lithium aluminium tetrahydride; In diethyl ether; at -10 ℃; for 0.5h;

With sodium chloride; In diethyl ether; at -10 - 20 ℃;

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tetrahydrofuran; water; tert-butyl alcohol; at 20 ℃; for 1.2h; Further stages.;
DOI:10.1002/anie.200600738