(2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine

Base Information

• Chemical Name: (2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine
• CAS No.: 904296-01-1
• Molecular Formula: C₁₃H₁₄F₃NO₂
• Molecular Weight: 273.255
• Mol file: 904296-01-1.mol

Synonyms:(2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine

Chemical Property of (2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine

There total 1 articles about (2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

propionyl chloride (79-03-8) + (4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine (1044222-31-2) → (2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine (904296-01-1) + (2R,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine

Guidance literature:

With pyridine; at 50 ℃; for 20h;

DOI:10.1002/anie.200600738

Reference yield: 90.0%

(2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine (904296-01-1) → (2S,4R)-2-trifluoromethyl-3-[(R)-2-hydroxypropanoyl]-4-phenyl-1,3-oxazolidine (1220352-21-5)

Guidance literature:

(2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.75h; Inert atmosphere;

With oxygen; triethyl phosphite; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/ol100211s

Reference yield: 90.0%

(2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine (904296-01-1) + benzyl bromide (100-39-0) → (2S,4R)-2-trifluoromethyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine (904296-09-9)

Guidance literature:

(2S,4R)-2-trifluoromethyl-4-phenyl-3-propanoyloxazolidine; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.5h; Inert atmosphere;

benzyl bromide; With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -78 ℃; for 2h; Reagent/catalyst; Solvent; optical yield given as %de; diastereoselective reaction; Reactivity;

DOI:10.1002/chem.200701604

upstream raw materials:

propionyl chloride

(4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

Downstream raw materials:

(2S,4R)-2-trifluoromethyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine

(2S,4R)-3-[(2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

(2S,4R)-3-[(2S,3S)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine

(2S,4R)-2-trifluoromethyl-3-[(R)-2-hydroxypropanoyl]-4-phenyl-1,3-oxazolidine