904296-01-1

Upstream product

• 79-03-8 propionyl chloride 
• 1044222-31-2 (4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine 

Downstream Products

• 904296-09-9 (2S,4R)-2-trifluoromethyl-3-[(S)-2-methyl-3-phenylpropanoyl]-4-phenyloxazolidine 
• 1428339-75-6 (2S,4R)-3-[(R)-2-fluoropropanoyl]-4-phenyl-2-trifluoromethyloxazolidine 
• 1220352-21-5 (2S,4R)-2-trifluoromethyl-3-[(R)-2-hydroxypropanoyl]-4-phenyl-1,3-oxazolidine 
• 1220352-23-7 (2S,4R)-2-trifluoromethyl-3-[(R)-2-hydroperoxypropanoyl]-4-phenyl-1,3-oxazolidine 
• 1220352-22-6 (2S,4R)-2-trifluoromethyl-3-[(S)-2-hydroxypropanoyl]-4-phenyl-1,3-oxazolidine 
• 1215007-33-2 (2S,4R)-3-[(2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine 
• 1215007-34-3 (2S,4R)-3-[(2S,3S)-3-hydroxy-2-methyl-3-phenylpropanoyl]-4-phenyl-2-trifluoromethyloxazolidine 

Relevant academic research and scientific papers

Chiral 4-phenyl-2-trifluoromethyloxazolidine: A high-performance chiral auxiliary for the alkylation of amides

(Chemical Equation Presented) A bit on the side: Extremely high diastereoselectivities (> 99% de) were attained in the α-alkylation and -allylation of amides by using a trifluoromethylated (sphere) oxazolidine as a chiral auxiliary. Reductive cleavage of the amide bond led to the recovery of this fluorinated chiral auxiliary in high yield.