3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide

Base Information

Chemical Name:3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide
CAS No.:1416973-63-1
Molecular Formula:C₃₀H₄₉ClN₈O₇
Molecular Weight:669.221
Hs Code.:

Synonyms:3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide

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Chemical Property of 3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of 3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide

There total 11 articles about 3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl((2S,3R_.4R,5R)-2,3,4,5,6-pentahydroxyl)amino)ethoxy)phenyl)butyl)carbamimimdoyl)pyrazine-2-carboxamide hydrochloride

: 1416973-63-1
3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide

Guidance literature:: With water; sodium hydroxide;

Reference yield:

: 587880-55-5
{4-[4-(2-tert-Butoxycarbonylaminoethoxy)phenyl]butyl}carbamic acid benzyl ester

: 1416973-63-1
3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2.1: acetic acid / methanol / 2 h / 20 °C

2.2: 20 °C

2.3: 20 °C

3.1: acetic acid; palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr

4.1: N-ethyl-N,N-diisopropylamine / ethanol / 2 h / 20 - 70 °C / Sealed tube

5.1: hydrogenchloride; water / ethanol / 4 h / 20 °C

6.1: water; sodium hydroxide

With hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; methanol; ethanol;

Reference yield:

: 587880-25-9
4-(4-hydroxyphenyl)butylcarbamic acid benzyl ester

: 1416973-63-1
3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3.1: acetic acid / methanol / 2 h / 20 °C

3.2: 20 °C

3.3: 20 °C

4.1: acetic acid; palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr

5.1: N-ethyl-N,N-diisopropylamine / ethanol / 2 h / 20 - 70 °C / Sealed tube

6.1: hydrogenchloride; water / ethanol / 4 h / 20 °C

7.1: water; sodium hydroxide

With hydrogenchloride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol;