N-(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)-2-chloroacetamide

Base Information

• Chemical Name: N-(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)-2-chloroacetamide
• CAS No.: 1607833-78-2
• Molecular Formula: C₁₄H₁₃ClN₂O₂
• Molecular Weight: 276.722
• Mol file: 1607833-78-2.mol

Synonyms:N-(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)-2-chloroacetamide

Chemical Property of N-(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)-2-chloroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)-2-chloroacetamide

There total 2 articles about N-(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)-2-chloroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

3-amino-6-methyl-4-phenylpyridine-2(1H)-one (1607833-75-9) + chloroacetyl chloride (79-04-9) → N-(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)-2-chloroacetamide (1607833-78-2)

Guidance literature:

With pyridine; In dichloromethane; at 5 - 20 ℃; for 15h;

DOI:10.1007/s10593-014-1464-9

Reference yield:

1-phenylbutan-1,3-dione (93-91-4) → N-(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)-2-chloroacetamide (1607833-78-2)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / benzene / 24 h / Reflux; Dean-Stark

2: butan-1-ol / Heating

3: hydrazine hydrate / 3 h / Heating

4: pyridine / dichloromethane / 15 h / 5 - 20 °C

With pyridine; hydrazine hydrate; toluene-4-sulfonic acid; In dichloromethane; butan-1-ol; benzene;

DOI:10.1007/s10593-014-1464-9

Reference yield: 71.0%

1,2,3,4,5,6-hexahydro-1,5-methano-pyrido[1,2-a][1,5]diazocin-8-one (15191-27-2) + N-(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)-2-chloroacetamide (1607833-78-2) → N-(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)-2-(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)acetamide

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; acetone; at 25 ℃;

DOI:10.1134/S1070363219120259

upstream raw materials:

3-amino-6-methyl-4-phenylpyridine-2(1H)-one

chloroacetyl chloride

1-phenylbutan-1,3-dione

Downstream raw materials:

6-methyl-8-phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one