1607833-75-9

Upstream product

• 1607833-71-5 N-(3-oxo-1-phenylbut-1-en-1-yl)-2-chloroacetamide 
• 1607833-73-7 C₁₇H₁₅N₂O⁽¹⁺⁾*Cl^(1-) 
• 93-91-4 1-phenylbutan-1,3-dione 
• 16232-41-0 6-methyl-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 57162-19-3 6-methyl-2-oxo-4-phenyl-1,2-dihydropyridine-3-carboxamide 
• 56-40-6 glycine 

Downstream Products

• 1607833-78-2 N-(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)-2-chloroacetamide 
• 1607833-80-6 6-methyl-8-phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one 
• 1607833-82-8 N,N'-bis(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)ethanediamide 

Relevant academic research and scientific papers

Synthesis and application of new 3-amino-2-pyridone based luminescent dyes for ELISA

A series of new 3-amino-4-arylpyridin-2(1H)-one derivatives was synthesized on the basis of oxazolo[5,4-b]pyridin-2(1H)-ones. Their photophysical properties and antioxidant activity were studied. Effective luminophores with an photoluminescence yield of up to 0.76 and substances exhibiting antioxidant activity exceeding ascorbic acid were revealed. It was found that the obtained luminescent dyes are horseradish peroxidase substrates and can be used to develop a rather sensitive ELISA method. The detection limits of hydrogen peroxide and horseradish peroxidase in the system containing the tested dyes lie in the nanomolar concentration range.

Synthesis and photophysical properties of the products of the reaction of 5-methyl-7-phenyl[1,3]oxazolo[5,4-b]pyridin-2(1H)-one with amino acids

[Figure not available: see fulltext.] The reaction of amino acid esters with 7-phenyl[1,3]oxazolo[5,4-b]pyridin-2(1H)-one led to the derivatives of 3-(2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)imidazolidine-2,4-diones and ethyl 2-[3-(2-oxo-4-phenyl-1,2-dihyd

Synthesis and Photophysical Properties of 3-Amino-4-arylpyridin-2(1 H)-ones

A method has been developed for the preparation of oxazolo-[5,4- b ]pyridin-2(1 H)-ones based on the Hoffmann reaction of 2-oxo-1,2-dihydropyridine-3-carboxamides. Hydrolysis of oxazolo[5,4- b ]pyridin-2(1 H)-ones and the Hoffmann reaction of 2-oxo-1,2-dihydropyridine-3-carboxamides yielded 3-aminopyridin-2(1 H)-ones, including 4-aryl substituted derivatives in the series, for which effective phosphors with a quantum yield of up to 0.78 were detected. Photophysical properties of 3-aminopyridin-2(1 H)-ones were studied by UV and luminescence spectroscopy methods, and the relationship between their structure and photophysical properties was revealed.

Synthesis of 3-amino-6-methyl-4-phenylpyridin-2(1H)-one and its derivatives

[Figure not available: see fulltext.] A reaction of 2-cyanoacetamide with benzylideneacetone in DMSO containing potassium tert-butoxide was used to synthesize 3-cyano-6-methyl-4-phenylpyridin-2(1H)-one, which was converted by acidic hydrolysis to 6-methyl-2-oxo-4-phenyl-1,2-dihydropyridine-3-carboxamide. A Hofmann reaction of this compound in the presence of sodium hypobromite led to 3-amino-5-bromo-6-methyl-4-phenylpyridin-2(1H)-one, while its treatment with calcium hypochlorite produced 5-methyl-7-phenyloxazolo[5,4-b]pyridin-2(1H)-one. The latter compound was converted by heating with alkali to 3-amino-6-methyl-4-phenylpyridin-2(1H)-one, which gave azomethine in a reaction with benzaldehyde, while N-acylated derivatives were obtained in reactions with acyl halides. The heating of N1,N2-bis(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)oxalylamide in the presence of POCl3 allowed to obtain 5,5'-dimethyl-7,7'-diphenyl-2,2'-bis-(oxazolo[5,4-b]pyridine).

Synthesis of 3-aminopyridin-2(1H)-ones and 1H-pyrido[2,3-b][1,4]oxazin- 2(3H)-ones

The interaction of 1,3-diketones with chloroacetamide produced N-(3-oxoalkenyl)chloroacetamides. Heating of N-(3-oxoalkenyl)chloroacetamides with an excess of pyridine in ethanol or butanol led to the formation of pyridin-2(1H)-ones, substituted with a py

Synthesis of 3-aminopyridin-2(1H)-ones and 1H-pyrido[2,3-b][1,4]oxazin-2(3H)-ones

The interaction of 1,3-diketones with chloroacetamide produced N-(3-oxoalkenyl)chloroacetamides. Heating of N-(3-oxoalkenyl)chloroacetamides with an excess of pyridine in ethanol or butanol led to the formation of pyridin-2(1H)-ones, substituted with a py