1-(3-Bromo-4-fluorophenyl)-2,2,2-trifluoroethanol

Base Information

Chemical Name:1-(3-Bromo-4-fluorophenyl)-2,2,2-trifluoroethanol
CAS No.:150698-79-6
Molecular Formula:C₈H₅BrF₄O
Molecular Weight:273.025
Hs Code.:
DSSTox Substance ID:DTXSID40601575

Synonyms:1-(3-BROMO-4-FLUOROPHENYL)-2,2,2-TRIFLUOROETHANOL;150698-79-6;1-(3-Bromo-4-fluorophenyl)-2,2,2-trifluoroethan-1-ol;MFCD16067892;SCHEMBL8848350;3-Bromo-4-fluoro-alpha-(trifluoromethyl)benzyl Alcohol;DTXSID40601575;AKOS010909784;PS-11407;SY249801;CS-0447087;EN300-1933182;2,2,2-trifluoro-1-(3-bromo-4-fluorophenyl)ethanol

Suppliers and Price of 1-(3-Bromo-4-fluorophenyl)-2,2,2-trifluoroethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 1-(3-Bromo-4-fluorophenyl)-2,2,2-trifluoroethanol

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:271.94599
Heavy Atom Count:14
Complexity:196

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1C(C(F)(F)F)O)Br)F

Technology Process of 1-(3-Bromo-4-fluorophenyl)-2,2,2-trifluoroethanol

There total 1 articles about 1-(3-Bromo-4-fluorophenyl)-2,2,2-trifluoroethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 77771-02-9
3-bromo-4-fluorobenzaldehyde

: 150698-79-6
1-(3-bromo-4-fluorophenyl)-2,2,2-trifluoroethanol

Guidance literature:: (trifluoromethyl)trimethylsilane; 3-bromo-4-fluorobenzaldehyde; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; N,N-dimethyl-formamide; Inert atmosphere;
DOI:10.1021/ol5030184

Reference yield: 85.0%

: 150698-79-6
1-(3-bromo-4-fluorophenyl)-2,2,2-trifluoroethanol

: 150698-74-1
2,2,2-trifluoro-3'-bromo-4’-fluoroacetophenone

Guidance literature:: With Oxone; sodium ortho-iodobenzenesulfonate; Inert atmosphere; Reflux;
DOI:10.1021/ol5030184

Reference yield:

: 150698-79-6
1-(3-bromo-4-fluorophenyl)-2,2,2-trifluoroethanol

: 2-bromo-4-(1-diazo-2,2,2-trifluoroethyl)-1-fluorobenzene

Guidance literature:: Multi-step reaction with 3 steps

1: Oxone; sodium ortho-iodobenzenesulfonate / Inert atmosphere; Reflux

2: methanol / 16 h / 20 - 65 °C / Inert atmosphere

3: potassium hydroxide / methanol / 1 h / 70 °C / Inert atmosphere

With Oxone; sodium ortho-iodobenzenesulfonate; potassium hydroxide; In methanol;
DOI:10.1021/ol5030184