3'-BROMO-4',2,2,2-TETRAFLUOROACETOPHENONE 98

Base Information

• Chemical Name: 3'-BROMO-4',2,2,2-TETRAFLUOROACETOPHENONE 98
• CAS No.: 150698-74-1
• Molecular Formula: C8H3 Br F4 O
• Molecular Weight: 271.0067
• Hs Code.: 2914790090
• Mol file: 150698-74-1.mol

Synonyms:3'-BROMO-4',2,2,2-TETRAFLUOROACETOPHENONE 98;3-BROMO-4,ALPHA,ALPHA,ALPHA-TETRAFLUOROACETOPHENONE;3'-Bromo-4',2,2,2-tetrafluoroacetophenone 98%

Chemical Property of 3'-BROMO-4',2,2,2-TETRAFLUOROACETOPHENONE 98

Chemical Property:

• Refractive Index: 1.475
• Boiling Point: 245.3°Cat760mmHg
• Flash Point: 102.2°C
• Density: 1.717g/cm³

Purity/Quality:

98%Min ^*data from raw suppliers

3'-Bromo-4',2,2,2-tetrafluoroacetophenone 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

Useful:

Technology Process of 3'-BROMO-4',2,2,2-TETRAFLUOROACETOPHENONE 98

There total 3 articles about 3'-BROMO-4',2,2,2-TETRAFLUOROACETOPHENONE 98 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,2,2-trifluoro-1-(4-fluorophenyl)ethanone (655-32-3) → 2,2,2-trifluoro-3'-bromo-4’-fluoroacetophenone (150698-74-1)

Guidance literature:

With N-Bromosuccinimide; sulfuric acid; at 60 ℃; for 16h;

Reference yield: 85.0%

1-(3-bromo-4-fluorophenyl)-2,2,2-trifluoroethanol (150698-79-6) → 2,2,2-trifluoro-3'-bromo-4’-fluoroacetophenone (150698-74-1)

Guidance literature:

With Oxone; sodium ortho-iodobenzenesulfonate; Inert atmosphere; Reflux;

DOI:10.1021/ol5030184

Reference yield:

3-bromo-4-fluorobenzaldehyde (77771-02-9) → 2,2,2-trifluoro-3'-bromo-4’-fluoroacetophenone (150698-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: Oxone; sodium ortho-iodobenzenesulfonate / Inert atmosphere; Reflux

With Oxone; sodium ortho-iodobenzenesulfonate; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/ol5030184

upstream raw materials:

1-(3-bromo-4-fluorophenyl)-2,2,2-trifluoroethanol

3-bromo-4-fluorobenzaldehyde

2,2,2-trifluoro-1-(4-fluorophenyl)ethanone

Refernces

• 1、 Emer, Enrico,Twilton, Jack,Tredwell, Matthew,Calderwood, Samuel,Collier, Thomas Lee,Ligault, Benot,Taillefer, Marc,Gouverneur, Vronique. "Diversity-oriented approach to CF3CHF-, CF3CFBr-, CF3CF2-, (CF3)2CH-, and CF3(SCF3)CH-substituted arenes from 1-(Diazo-2,2,2-trifluoroethyl)arenes". supporting information. p. 6004 - 6007. Retrieved 2015/01/09.