6-((5-(4-carbamoyl-3,5-difluorophenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)methyl)quinoline 1-oxide

Base Information

Chemical Name:6-((5-(4-carbamoyl-3,5-difluorophenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)methyl)quinoline 1-oxide
CAS No.:1459732-34-3
Molecular Formula:C₂₂H₁₄F₂N₆O₂
Molecular Weight:432.389
Hs Code.:

Synonyms:6-((5-(4-carbamoyl-3,5-difluorophenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)methyl)quinoline 1-oxide

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Chemical Property of 6-((5-(4-carbamoyl-3,5-difluorophenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)methyl)quinoline 1-oxide

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Technology Process of 6-((5-(4-carbamoyl-3,5-difluorophenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)methyl)quinoline 1-oxide

There total 12 articles about 6-((5-(4-carbamoyl-3,5-difluorophenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)methyl)quinoline 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1350427-59-6
2,6-difluoro-4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)benzamide

: 1459732-34-3
6-((5-(4-carbamoyl-3,5-difluorophenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)methyl)quinoline 1-oxide

Guidance literature:: With Oxone; In water; acetone; at 20 ℃; for 12h;

Reference yield:

: 5382-43-4
quinoline-6-carboxamide

: 1459732-34-3
6-((5-(4-carbamoyl-3,5-difluorophenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)methyl)quinoline 1-oxide

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine; trifluoroacetic anhydride / chloroform / 1.5 h / 10 °C

2.1: ammonia; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

3.1: sodium carbonate / ethanol / 12 h / 0 - 20 °C

4.1: tin(ll) chloride; hydrogenchloride / water / 2 h / 20 °C

5.1: acetic acid; sodium nitrite; sulfuric acid / water / 0.5 h / 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / 1,4-dioxane / 20 °C / Inert atmosphere; Reflux

7.1: lithium hydroxide; water / methanol; tetrahydrofuran / 12 h / 20 °C

8.1: thionyl chloride / 3 h / Reflux

8.2: 0.25 h / 0 °C

9.1: Oxone / water; acetone / 12 h / 20 °C

With hydrogenchloride; Oxone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sulfuric acid; ammonia; water; hydrogen; potassium acetate; sodium carbonate; acetic acid; triethylamine; trifluoroacetic anhydride; tin(ll) chloride; lithium hydroxide; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform; water; acetone;

Reference yield:

: 99071-54-2
quinolin-6-ylmethanamine

: 1459732-34-3
6-((5-(4-carbamoyl-3,5-difluorophenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)methyl)quinoline 1-oxide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / ethanol / 12 h / 0 - 20 °C

2.1: tin(ll) chloride; hydrogenchloride / water / 2 h / 20 °C

3.1: acetic acid; sodium nitrite; sulfuric acid / water / 0.5 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / 1,4-dioxane / 20 °C / Inert atmosphere; Reflux

5.1: lithium hydroxide; water / methanol; tetrahydrofuran / 12 h / 20 °C

6.1: thionyl chloride / 3 h / Reflux

6.2: 0.25 h / 0 °C

7.1: Oxone / water; acetone / 12 h / 20 °C

With hydrogenchloride; Oxone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sulfuric acid; water; potassium acetate; sodium carbonate; acetic acid; tin(ll) chloride; lithium hydroxide; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; acetone;