2-benzyloxy-9H-3,4,9-triaza-fluorene-1-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2-benzyloxy-9H-3,4,9-triaza-fluorene-1-carboxylic acid ethyl ester
• CAS No.: 615286-52-7
• Molecular Formula: C₂₀H₁₇N₃O₃
• Molecular Weight: 347.373
• Mol file: 615286-52-7.mol

Synonyms:2-benzyloxy-9H-3,4,9-triaza-fluorene-1-carboxylic acid ethyl ester

Chemical Property of 2-benzyloxy-9H-3,4,9-triaza-fluorene-1-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyloxy-9H-3,4,9-triaza-fluorene-1-carboxylic acid ethyl ester

There total 1 articles about 2-benzyloxy-9H-3,4,9-triaza-fluorene-1-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

benzyl bromide (100-39-0) + 3-hydroxy-5H-pyridazino[4,3-b]indole-4-carboxylic acid ethyl ester (446064-40-0) → 2-benzyloxy-9H-3,4,9-triaza-fluorene-1-carboxylic acid ethyl ester (615286-52-7) + 9-benzyl-2-benzyloxy-9H-3,4,9-triaza-fluorene-1-carboxylic acid ethyl ester

Guidance literature:

3-hydroxy-5H-pyridazino[4,3-b]indole-4-carboxylic acid ethyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1016/S0014-827X(02)00017-4

Reference yield: 61.0%

ethyl iodide (75-03-6) + 2-benzyloxy-9H-3,4,9-triaza-fluorene-1-carboxylic acid ethyl ester (615286-52-7) → 2-benzyloxy-9-ethyl-9H-3,4,9-triaza-fluorene-1-carboxylic acid ethyl ester (615286-54-9)

Guidance literature:

2-benzyloxy-9H-3,4,9-triaza-fluorene-1-carboxylic acid ethyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.666667h;

ethyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1016/S0014-827X(02)00017-4

Reference yield:

2-benzyloxy-9H-3,4,9-triaza-fluorene-1-carboxylic acid ethyl ester (615286-52-7) → 2-benzyloxy-9-ethyl-9H-3,4,9-triaza-fluorene-1-carbonyl chloride

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.67 h / 20 °C

1.2: 61 percent / dimethylformamide / 1 h / 20 °C

2.1: 76 percent / NaOH / ethanol / 2 h / Heating

3.1: SOCl₂ / dimethylformamide / 7 h / Heating

With sodium hydroxide; thionyl chloride; sodium hydride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/S0014-827X(02)00017-4

upstream raw materials:

benzyl bromide

3-hydroxy-5H-pyridazino[4,3-b]indole-4-carboxylic acid ethyl ester

Downstream raw materials:

2-benzyloxy-9-ethyl-9H-3,4,9-triaza-fluorene-1-carboxylic acid ethyl ester

3-benzyloxy-5-ethyl-5H-pyridazino[4,3-b]indole-4-carboxylic acid