methyl trans-3,5,6-trimethoxy-4-trimethylsilyl-2-pivaloylaminocinnamate

Base Information

Chemical Name:methyl trans-3,5,6-trimethoxy-4-trimethylsilyl-2-pivaloylaminocinnamate
CAS No.:170959-07-6
Molecular Formula:C₂₁H₃₃NO₆Si
Molecular Weight:423.582
Hs Code.:

Synonyms:methyl trans-3,5,6-trimethoxy-4-trimethylsilyl-2-pivaloylaminocinnamate

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Chemical Property of methyl trans-3,5,6-trimethoxy-4-trimethylsilyl-2-pivaloylaminocinnamate

Chemical Property:

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Technology Process of methyl trans-3,5,6-trimethoxy-4-trimethylsilyl-2-pivaloylaminocinnamate

There total 5 articles about methyl trans-3,5,6-trimethoxy-4-trimethylsilyl-2-pivaloylaminocinnamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 170959-16-7
6-iodo-2,4,5-trimethoxy-3-trimethylsilylpivaloylaminobenzene

: 170959-07-6
methyl trans-3,5,6-trimethoxy-4-trimethylsilyl-2-pivaloylaminocinnamate

Guidance literature:: With palladium diacetate; triethylamine; In acetonitrile; at 140 ℃; for 120h;
DOI:10.1002/jhet.5570320411

Reference yield:

: 26510-91-8
2,4,5-trimethoxyaniline

: 170959-07-6
methyl trans-3,5,6-trimethoxy-4-trimethylsilyl-2-pivaloylaminocinnamate

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / Et₃N / diethyl ether / 16 h / Ambient temperature

2: 1.) n-BuLi, TMEDA / 1.) THF, hexane, 0 deg C, 4 h, 2.) THF, hexane, 0 deg C, 2 h

3: 1.) n-BuLi, TMEDA, 2.) I₂ / 1.) THF, hexane, 0 deg C, 2 h, 2.) THF, hexane, 0 deg C, 2 h

4: 76 percent / Pd(OAc)2, Et₃N / acetonitrile / 120 h / 140 °C

With palladium diacetate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; iodine; triethylamine; In diethyl ether; acetonitrile;
DOI:10.1002/jhet.5570320411

Reference yield:

: 3282-30-2
pivaloyl chloride

: 170959-07-6
methyl trans-3,5,6-trimethoxy-4-trimethylsilyl-2-pivaloylaminocinnamate

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / Et₃N / diethyl ether / 16 h / Ambient temperature

2: 1.) n-BuLi, TMEDA / 1.) THF, hexane, 0 deg C, 4 h, 2.) THF, hexane, 0 deg C, 2 h

3: 1.) n-BuLi, TMEDA, 2.) I₂ / 1.) THF, hexane, 0 deg C, 2 h, 2.) THF, hexane, 0 deg C, 2 h

4: 76 percent / Pd(OAc)2, Et₃N / acetonitrile / 120 h / 140 °C

With palladium diacetate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; iodine; triethylamine; In diethyl ether; acetonitrile;
DOI:10.1002/jhet.5570320411