[3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methanol

Base Information

Chemical Name:[3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methanol
CAS No.:1345983-74-5
Molecular Formula:C₂₅H₃₅NO₂S
Molecular Weight:413.624
Hs Code.:

Synonyms:[3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methanol

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Chemical Property of [3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methanol

Chemical Property:

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Technology Process of [3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methanol

There total 16 articles about [3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1345983-73-4
[3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3-dihydro-1,4-benzothiazepin-8-yl]methanol

: 1345983-74-5
[3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methanol

Guidance literature:: [3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3-dihydro-1,4-benzothiazepin-8-yl]methanol; With borane-THF; In tetrahydrofuran; at 25 ℃; for 2h;

With methanol; In tetrahydrofuran;

Reference yield:

: 98-88-4
benzoyl chloride

: 1345983-74-5
[3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methanol

Guidance literature:: Multi-step reaction with 9 steps

1.1: trifluorormethanesulfonic acid / dichloromethane / 49 h / 5 - 20 °C / Reflux

2.1: boron trichloride / dichloromethane / 0.5 h / 0 - 5 °C

2.2: 0.5 h / 10 °C

2.3: 0.5 h / 15 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C

3.2: 3 h / 60 °C

4.1: diphenylether / 4.5 h / 215 °C

5.1: potassium hydroxide / ethanol; water / 18 h / 70 °C / Reflux

5.2: 15 h / 85 °C

6.1: citric acid / toluene / 50 h / 130 °C / Reflux

7.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 42 h / 70 °C

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 25 °C

8.2: 0.5 h

9.1: borane-THF / tetrahydrofuran / 2 h / 25 °C

With lithium aluminium tetrahydride; borane-THF; trifluorormethanesulfonic acid; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; boron trichloride; triethylamine; citric acid; potassium hydroxide; palladium diacetate; In tetrahydrofuran; diphenylether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 616-06-8
2-amino-hexanoic acid

: 1345983-74-5
[3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methanol

Guidance literature:: Multi-step reaction with 11 steps

1.1: thionyl chloride / 0 - 65 °C

2.1: magnesium sulfate; triethylamine / dichloromethane / 2 h / 25 °C

2.2: 0.5 h

2.3: 60 h / 25 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 25 °C

3.2: 20 h / 25 °C

4.1: hydrogenchloride; water / 0.5 h / 25 °C

4.2: 0 °C / pH 12

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 - 65 °C

5.2: 2 h / 0 °C

6.1: chlorosulfonic acid / ethyl acetate / 3 h / 25 - 40 °C

7.1: potassium hydroxide / ethanol; water / 18 h / 70 °C / Reflux

7.2: 15 h / 85 °C

8.1: citric acid / toluene / 50 h / 130 °C / Reflux

9.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 42 h / 70 °C

10.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 25 °C

10.2: 0.5 h

11.1: borane-THF / tetrahydrofuran / 2 h / 25 °C

With hydrogenchloride; chlorosulfonic acid; lithium aluminium tetrahydride; thionyl chloride; borane-THF; 1,3-bis-(diphenylphosphino)propane; water; sodium hydride; magnesium sulfate; triethylamine; citric acid; potassium hydroxide; palladium diacetate; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;