ethyl 2-(2-phenylethyl) crotonate

Base Information

• Chemical Name: ethyl 2-(2-phenylethyl) crotonate
• CAS No.: 168912-16-1
• Molecular Formula: C₁₄H₁₈O₂
• Molecular Weight: 218.296
• Mol file: 168912-16-1.mol

Synonyms:ethyl 2-(2-phenylethyl) crotonate

Chemical Property of ethyl 2-(2-phenylethyl) crotonate

Chemical Property:

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Technology Process of ethyl 2-(2-phenylethyl) crotonate

There total 1 articles about ethyl 2-(2-phenylethyl) crotonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

1-phenyl-2-bromoethane (103-63-9) + ethyl (E)-crotonate (623-70-1) → ethyl 2-(2-phenylethyl) crotonate (168912-16-1)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; at -78 ℃; for 5h;

DOI:10.1016/0040-4020(95)00459-L

Reference yield: 80.0%

ethylene dibromide (106-93-4) + ethyl 2-(2-phenylethyl) crotonate (168912-16-1) → ethyl 2-(2-phenylethyl)-5-bromo-2-vinyl-butyrate

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; at -78 ℃;

DOI:10.1016/0040-4020(95)00459-L

Reference yield: 78.0%

1,3-dibromo-propane (109-64-8) + ethyl 2-(2-phenylethyl) crotonate (168912-16-1) → ethyl 2-(2-phenylethyl)-5-bromo-2-vinyl-pentanoate

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; at -78 ℃;

DOI:10.1016/0040-4020(95)00459-L

upstream raw materials:

1-phenyl-2-bromoethane

ethyl (E)-crotonate