4-amino-2,5-difluorophenylmethanol

Base Information

Chemical Name:4-amino-2,5-difluorophenylmethanol
CAS No.:1346764-06-4
Molecular Formula:C₇H₇F₂NO
Molecular Weight:159.135
Hs Code.:

Synonyms:

Suppliers and Price of 4-amino-2,5-difluorophenylmethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-amino-2,5-difluorophenylmethanol

Chemical Property:

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Technology Process of 4-amino-2,5-difluorophenylmethanol

There total 5 articles about 4-amino-2,5-difluorophenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 952285-52-8
methyl 4-amino-2,5-difluorobenzoate

: 1346764-06-4
4-amino-2,5-difluorophenylmethanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 25 ℃;
DOI:10.1021/acs.bioconjchem.7b00665

Reference yield:

: 773108-64-8
4-amino-2,5-difluoro-benzoic acid

: 1346764-06-4
4-amino-2,5-difluorophenylmethanol

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 65 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 25 °C

With lithium aluminium tetrahydride; sulfuric acid; In tetrahydrofuran;
DOI:10.1021/acs.bioconjchem.7b00665

Reference yield:

: 112279-60-4
4-bromo-2,5-difluoroaniline

: 1346764-06-4
4-amino-2,5-difluorophenylmethanol

Guidance literature:: Multi-step reaction with 4 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium acetate / water; 1,4-dioxane / 125 °C

2: potassium hydroxide / water / 100 °C

3: sulfuric acid / 65 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 25 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; sulfuric acid; sodium acetate; potassium hydroxide; XPhos; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/acs.bioconjchem.7b00665