4-<2-(2-hydroxyethoxy)ethyl>benzonitrile

Base Information

Chemical Name:4-<2-(2-hydroxyethoxy)ethyl>benzonitrile
CAS No.:86902-19-4
Molecular Formula:C₁₁H₁₃NO₂
Molecular Weight:191.23
Hs Code.:

Synonyms:4-<2-(2-hydroxyethoxy)ethyl>benzonitrile

Suppliers and Price of 4-<2-(2-hydroxyethoxy)ethyl>benzonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-<2-(2-hydroxyethoxy)ethyl>benzonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-<2-(2-hydroxyethoxy)ethyl>benzonitrile

There total 7 articles about 4-<2-(2-hydroxyethoxy)ethyl>benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 917226-72-3
2-[2-(4-bromophenyl)ethoxy]ethanol

: 544-92-3
copper(I) cyanide

: 86902-19-4
4-<2-(2-hydroxyethoxy)ethyl>benzonitrile

Guidance literature:: In N,N-dimethyl-formamide; at 140 - 150 ℃; Heating / reflux;

Reference yield:

: 60-12-8
2-phenylethanol

: 86902-19-4
4-<2-(2-hydroxyethoxy)ethyl>benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, 60 deg C, 10 min, 2.) DMF, 60 deg C, 30 min

2: 92 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

3: 0.5 h / 50 °C

4: 1.) HNO₃, 2.) 2percent ethanol. HCl / 1.) from -20 deg C to -15 deg C, 30 min, 2.) reflux, 1 h

5: 100 percent / H₂ / 10percent Pd/C / ethanol / 1.25 h / Ambient temperature

6: 1.) NaNO₂, aq. HCl, 2.) Na₂CO₃ / 1.) from -5 deg C to 0 deg C, 2.) H₂O, toluene, 50 deg C, 5 min

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; nitric acid; sodium hydride; sodium carbonate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00365a005

Reference yield:

: 81228-03-7
2-phenethyloxyacetic acid

: 86902-19-4
4-<2-(2-hydroxyethoxy)ethyl>benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

2: 0.5 h / 50 °C

3: 1.) HNO₃, 2.) 2percent ethanol. HCl / 1.) from -20 deg C to -15 deg C, 30 min, 2.) reflux, 1 h

4: 100 percent / H₂ / 10percent Pd/C / ethanol / 1.25 h / Ambient temperature

5: 1.) NaNO₂, aq. HCl, 2.) Na₂CO₃ / 1.) from -5 deg C to 0 deg C, 2.) H₂O, toluene, 50 deg C, 5 min

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; nitric acid; sodium carbonate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00365a005