2,5-dioxopyrrolidine-1-yl 3,5-di-tert-butyl-2-hydroxybenzoate

Base Information

• Chemical Name: 2,5-dioxopyrrolidine-1-yl 3,5-di-tert-butyl-2-hydroxybenzoate
• CAS No.: 512802-95-8
• Molecular Formula: C₁₉H₂₅NO₅
• Molecular Weight: 347.411
• Mol file: 512802-95-8.mol

Synonyms:2,5-dioxopyrrolidine-1-yl 3,5-di-tert-butyl-2-hydroxybenzoate

Chemical Property of 2,5-dioxopyrrolidine-1-yl 3,5-di-tert-butyl-2-hydroxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-dioxopyrrolidine-1-yl 3,5-di-tert-butyl-2-hydroxybenzoate

There total 2 articles about 2,5-dioxopyrrolidine-1-yl 3,5-di-tert-butyl-2-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 3,5-ditertbutyl salicylic acid (19715-19-6) → 2,5-dioxopyrrolidine-1-yl 3,5-di-tert-butyl-2-hydroxybenzoate (512802-95-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In 1,4-dioxane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201101509

Reference yield:

methyl 3,5‐di‐tert-butyl‐2‐hydroxybenzoate (15018-03-8) → 2,5-dioxopyrrolidine-1-yl 3,5-di-tert-butyl-2-hydroxybenzoate (512802-95-8)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / methanol; H₂O

2: 74 percent / dioxane / 24 h / 20 °C

With potassium hydroxide; In 1,4-dioxane; methanol; water;

DOI:10.1016/j.tet.2005.02.064

Reference yield: 86.0%

2,5-dioxopyrrolidine-1-yl 3,5-di-tert-butyl-2-hydroxybenzoate (512802-95-8) + ethanolamine (141-43-5) → 3,5-di-tert-butyl-2-hydroxy-N-(2-hydroxyethyl)-benzamide (1314802-39-5)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 24h; Inert atmosphere;

DOI:10.1002/chem.201101509

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

3,5-ditertbutyl salicylic acid

methyl 3,5‐di‐tert-butyl‐2‐hydroxybenzoate

Downstream raw materials:

1,2-bis-(3,5-di-tert-butyl-2-hydroxybenzamido)ethane

1,2-bis-(3,5-di-tert-butyl-2-hydroxybenzamido)propane

tetrabutylammonium 2,4-di-tert-butyl-6-(dimethylcarbamoyl)phenolate

tetrabutylammonium 2,4-di-tert-butyl-6-(methylcarbamoyl)phenolate