(5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

Base Information

Chemical Name:(5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine
CAS No.:1443035-45-7
Molecular Formula:C₁₂H₁₀BrF₃N₂O
Molecular Weight:335.123
Hs Code.:

Synonyms:(5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

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Technology Process of (5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

There total 12 articles about (5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1443035-43-5
(5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methylmorpholin-3-thione

: 1443035-45-7
(5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

Guidance literature:: With ammonia; In methanol; at 80 ℃; for 2h;

Reference yield: 72.0%

: 1443035-45-7
(5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

Guidance literature:: With ammonia; In methanol; at 60 ℃; for 36h;

Reference yield:

: 1443035-39-9
(5R)-5-(5-bromo-2-fluorophenyl)-6-chloro-5-methyl-6-(trifluoromethyl)morpholin-3-one

: 1443035-45-7
(5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; zinc-copper couple / 16 h / 20 °C

2: tetraphosphorus decasulfide / tetrahydrofuran / 1.5 h / 20 - 70 °C

3: ammonia / methanol / 2 h / 80 °C

With tetraphosphorus decasulfide; zinc-copper couple; ammonia; acetic acid; In tetrahydrofuran; methanol;