N-{3-(3R)-(5-amino-2-(difluoromethylene)-3-methyl-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide

Base Information

Chemical Name:N-{3-(3R)-(5-amino-2-(difluoromethylene)-3-methyl-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide
CAS No.:1443035-49-1
Molecular Formula:C₁₈H₁₆F₃N₅O₃
Molecular Weight:407.352
Hs Code.:

Synonyms:N-{3-(3R)-(5-amino-2-(difluoromethylene)-3-methyl-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide

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Chemical Property of N-{3-(3R)-(5-amino-2-(difluoromethylene)-3-methyl-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide

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Technology Process of N-{3-(3R)-(5-amino-2-(difluoromethylene)-3-methyl-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide

There total 13 articles about N-{3-(3R)-(5-amino-2-(difluoromethylene)-3-methyl-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1443035-47-9
(5R)-5-(5-amino-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

: 40155-42-8
5-methoxy-pyrazine-2-carboxylic acid

: 1443035-49-1
N-{3-(3R)-(5-amino-2-(difluoromethylene)-3-methyl-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide

Guidance literature:: 5-methoxy-pyrazine-2-carboxylic acid; With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; for 0.0833333h;

(5R)-5-(5-amino-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine; In methanol; at 0 - 20 ℃; for 16h;

Reference yield:

: 1443035-39-9
(5R)-5-(5-bromo-2-fluorophenyl)-6-chloro-5-methyl-6-(trifluoromethyl)morpholin-3-one

: 1443035-49-1
N-{3-(3R)-(5-amino-2-(difluoromethylene)-3-methyl-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; zinc-copper couple / 16 h / 20 °C

2.1: tetraphosphorus decasulfide / tetrahydrofuran / 1.5 h / 20 - 70 °C

3.1: ammonia / methanol / 2 h / 80 °C

4.1: sodium azide; copper(l) iodide; sodium carbonate; N,N`-dimethylethylenediamine / dimethyl sulfoxide / 3 h / 110 °C

5.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0.08 h

5.2: 16 h / 0 - 20 °C

With copper(l) iodide; sodium azide; tetraphosphorus decasulfide; zinc-copper couple; ammonia; sodium carbonate; acetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; N,N`-dimethylethylenediamine; In tetrahydrofuran; methanol; dimethyl sulfoxide;

Reference yield:

: 1443035-41-3
(5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methylmorpholin-3-one

: 1443035-49-1
N-{3-(3R)-(5-amino-2-(difluoromethylene)-3-methyl-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetraphosphorus decasulfide / tetrahydrofuran / 1.5 h / 20 - 70 °C

2.1: ammonia / methanol / 2 h / 80 °C

3.1: sodium azide; copper(l) iodide; sodium carbonate; N,N`-dimethylethylenediamine / dimethyl sulfoxide / 3 h / 110 °C

4.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0.08 h

4.2: 16 h / 0 - 20 °C

With copper(l) iodide; sodium azide; tetraphosphorus decasulfide; ammonia; sodium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; N,N`-dimethylethylenediamine; In tetrahydrofuran; methanol; dimethyl sulfoxide;