6-(tert-butyldiphenylsilyloxy)-5-methyl-2-methylenehexane-1,5-diol

Base Information

• Chemical Name: 6-(tert-butyldiphenylsilyloxy)-5-methyl-2-methylenehexane-1,5-diol
• CAS No.: 1012075-09-0
• Molecular Formula: C₂₄H₃₄O₃Si
• Molecular Weight: 398.618
• Mol file: 1012075-09-0.mol

Synonyms:6-(tert-butyldiphenylsilyloxy)-5-methyl-2-methylenehexane-1,5-diol

Chemical Property of 6-(tert-butyldiphenylsilyloxy)-5-methyl-2-methylenehexane-1,5-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(tert-butyldiphenylsilyloxy)-5-methyl-2-methylenehexane-1,5-diol

There total 1 articles about 6-(tert-butyldiphenylsilyloxy)-5-methyl-2-methylenehexane-1,5-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(RS)-2-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-oxirane (123067-91-4) + 3-hydroxy-2-methyl-1-propene (513-42-8) → 6-(tert-butyldiphenylsilyloxy)-5-methyl-2-methylenehexane-1,5-diol (1012075-09-0)

Guidance literature:

3-hydroxy-2-methyl-1-propene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; for 25h; cooling;

With magnesium bromide; In diethyl ether; cooling;

(RS)-2-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-oxirane; In tetrahydrofuran; diethyl ether; at 20 ℃; for 2h; Further stages.;

DOI:10.1021/jo702620e

Reference yield: 93.0%

6-(tert-butyldiphenylsilyloxy)-5-methyl-2-methylenehexane-1,5-diol (1012075-09-0) + acetic anhydride (108-24-7) → 6-(tert-butyldiphenylsilyloxy)-5-hydroxy-5-methyl-2-methylenehexyl acetate (1012075-32-9)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jo702620e

Reference yield: 38.0%

6-(tert-butyldiphenylsilyloxy)-5-methyl-2-methylenehexane-1,5-diol (1012075-09-0) → (tert-butyl)(2-methyl-5-methylenetetrahydropyran-2-ylmethoxy)diphenylsilane (1012075-20-5)

Guidance literature:

With titanium(IV) isopropylate; 4 A molecular sieve; triphenylphosphine; palladium diacetate; In toluene; for 1.5h; Heating;

DOI:10.1021/jo702620e

upstream raw materials:

(RS)-2-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-oxirane

3-hydroxy-2-methyl-1-propene

Downstream raw materials:

(tert-butyl)(2-methyl-5-methylenetetrahydropyran-2-ylmethoxy)diphenylsilane

6-(tert-butyldiphenylsilyloxy)-5-hydroxy-5-methyl-2-methylenehexyl acetate