Technology Process of 7-(3-isopropoxy-4-methoxyphenyl)-3-oxoheptanoic acid methyl ester
There total 5 articles about 7-(3-isopropoxy-4-methoxyphenyl)-3-oxoheptanoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
acetoacetic acid methyl ester;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at 0 ℃;
for 0.333333h;
3-(3-isopropyloxy-4-methoxyphenyl)propyl iodide;
In
tetrahydrofuran;
at 0 ℃;
for 0.333333h;
DOI:10.1021/jo981844s
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 96 percent / K2CO3 / dimethylformamide / 24 h / 60 °C
2.1: 97 percent / LAH / tetrahydrofuran / 45 h / 0 °C
3.1: pyridine / 20 °C
4.1: 1.31 g / NaI / acetone / Heating
5.1: LDA / tetrahydrofuran / 0.33 h / 0 °C
5.2: 80 percent / tetrahydrofuran / 0.33 h / 0 °C
With
pyridine; lithium aluminium tetrahydride; potassium carbonate; sodium iodide; lithium diisopropyl amide;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetone;
1.1: Etherification / 2.1: Reduction / 3.1: Tosylation / 4.1: Substitution / 5.1: Metallation / 5.2: Alkylation;
DOI:10.1021/jo981844s
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 97 percent / LAH / tetrahydrofuran / 45 h / 0 °C
2.1: pyridine / 20 °C
3.1: 1.31 g / NaI / acetone / Heating
4.1: LDA / tetrahydrofuran / 0.33 h / 0 °C
4.2: 80 percent / tetrahydrofuran / 0.33 h / 0 °C
With
pyridine; lithium aluminium tetrahydride; sodium iodide; lithium diisopropyl amide;
In
tetrahydrofuran; acetone;
1.1: Reduction / 2.1: Tosylation / 3.1: Substitution / 4.1: Metallation / 4.2: Alkylation;
DOI:10.1021/jo981844s
