2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionyl chloride

Base Information

Chemical Name:2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionyl chloride
CAS No.:1003013-87-3
Molecular Formula:C₁₄H₁₄Cl₂O₄S
Molecular Weight:349.235
Hs Code.:

Synonyms:2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionyl chloride

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Chemical Property of 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionyl chloride

Chemical Property:

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Technology Process of 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionyl chloride

There total 8 articles about 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1003013-86-2
2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionic acid

: 1003013-87-3
2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionyl chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 25 ℃; for 1h; Product distribution / selectivity;

Reference yield:

: 1003013-83-9
3-iodomethyl-1,1-dimethoxy-cyclobutane

: 1003013-87-3
2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran; hexanes / 0.83 h / -78 - 0 °C / Cooling with acetone-dry ice

1.2: 21 h / -78 - 0 °C

2.1: sulfuric acid; water / 1,4-dioxane / 19.5 h / 25 °C / Heating / reflux

3.1: sodium periodate / methanol; water / 6 h / 25 °C

4.1: potassium permanganate / methanol; water / 3 h / 0 - 25 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 25 °C

With potassium permanganate; sodium periodate; n-butyllithium; oxalyl dichloride; sulfuric acid; water; 1,1,1,3,3,3-hexamethyl-disilazane; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; methanol; hexanes; dichloromethane; water;

Reference yield:

: 1003013-84-0
2(R)-(3-chloro-4-methylsulfanyl-phenyl)-3-(3,3-dimethoxy-cyclobutyl)-N-(2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl)-N-methyl-propionamide

: 1003013-87-3
2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; water / 1,4-dioxane / 19.5 h / 25 °C / Heating / reflux

2: sodium periodate / methanol; water / 6 h / 25 °C

3: potassium permanganate / methanol; water / 3 h / 0 - 25 °C

4: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 25 °C

With potassium permanganate; sodium periodate; oxalyl dichloride; sulfuric acid; water; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; dichloromethane; water;