2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionic acid

Base Information

Chemical Name:2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionic acid
CAS No.:1003013-86-2
Molecular Formula:C₁₄H₁₅ClO₅S
Molecular Weight:330.789
Hs Code.:

Synonyms:2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionic acid

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Chemical Property of 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionic acid

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Technology Process of 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionic acid

There total 7 articles about 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₅ClO₄S

: 1003013-86-2
2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionic acid

Guidance literature:: With potassium permanganate; In methanol; water; at 0 - 25 ℃; for 3h; Product distribution / selectivity;

Reference yield:

: 23761-23-1
3-oxocyclobutanecarboxylic acid

: 1003013-86-2
2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid / methanol / 2 h / Heating / reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 17 h / 0 - 25 °C

3.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / 0 - 25 °C

4.1: n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran; hexanes / 0.83 h / -78 - 0 °C / Cooling with acetone-dry ice

4.2: 21 h / -78 - 0 °C

5.1: sulfuric acid; water / 1,4-dioxane / 19.5 h / 25 °C / Heating / reflux

6.1: sodium periodate / methanol; water / 6 h / 25 °C

7.1: potassium permanganate / methanol; water / 3 h / 0 - 25 °C

With 1H-imidazole; potassium permanganate; sodium periodate; lithium aluminium tetrahydride; n-butyllithium; sulfuric acid; water; iodine; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; methanol; hexanes; dichloromethane; water;

Reference yield:

: 1003013-85-1
2(R)-(3-chloro-4-methylsulfanyl-phenyl)-3-(3-oxo-cyclobutyl)-propionic acid

: 1003013-86-2
2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium periodate / methanol; water / 6 h / 25 °C

2: potassium permanganate / methanol; water / 3 h / 0 - 25 °C

With potassium permanganate; sodium periodate; In methanol; water;