2(R)-(3-chloro-4-methylsulfanyl-phenyl)-3-(3,3-dimethoxy-cyclobutyl)-N-(2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl)-N-methyl-propionamide

Base Information

Chemical Name:2(R)-(3-chloro-4-methylsulfanyl-phenyl)-3-(3,3-dimethoxy-cyclobutyl)-N-(2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl)-N-methyl-propionamide
CAS No.:1003013-84-0
Molecular Formula:C₂₆H₃₄ClNO₄S
Molecular Weight:492.079
Hs Code.:

Synonyms:2(R)-(3-chloro-4-methylsulfanyl-phenyl)-3-(3,3-dimethoxy-cyclobutyl)-N-(2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl)-N-methyl-propionamide

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Chemical Property of 2(R)-(3-chloro-4-methylsulfanyl-phenyl)-3-(3,3-dimethoxy-cyclobutyl)-N-(2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl)-N-methyl-propionamide

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Technology Process of 2(R)-(3-chloro-4-methylsulfanyl-phenyl)-3-(3,3-dimethoxy-cyclobutyl)-N-(2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl)-N-methyl-propionamide

There total 4 articles about 2(R)-(3-chloro-4-methylsulfanyl-phenyl)-3-(3,3-dimethoxy-cyclobutyl)-N-(2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl)-N-methyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1003013-83-9
3-iodomethyl-1,1-dimethoxy-cyclobutane

: 1003013-84-0
2(R)-(3-chloro-4-methylsulfanyl-phenyl)-3-(3,3-dimethoxy-cyclobutyl)-N-(2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl)-N-methyl-propionamide

Guidance literature:: (3-chloro-4-methylsulfanyl-phenyl)-N-[2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl]-N-methyl acetamide; With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; hexanes; at -78 - 0 ℃; for 0.833333h; Cooling with acetone-dry ice;

3-iodomethyl-1,1-dimethoxy-cyclobutane; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; hexanes; at -78 - 0 ℃; for 21h;

Reference yield:

: 23761-23-1
3-oxocyclobutanecarboxylic acid

: 1003013-84-0
2(R)-(3-chloro-4-methylsulfanyl-phenyl)-3-(3,3-dimethoxy-cyclobutyl)-N-(2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl)-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / methanol / 2 h / Heating / reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 17 h / 0 - 25 °C

3.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / 0 - 25 °C

4.1: n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran; hexanes / 0.83 h / -78 - 0 °C / Cooling with acetone-dry ice

4.2: 21 h / -78 - 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; iodine; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; hexanes; dichloromethane;

Reference yield:

: 175021-11-1
(3,3-bis-methoxy-cyclobutyl)methanol

: 1003013-84-0
2(R)-(3-chloro-4-methylsulfanyl-phenyl)-3-(3,3-dimethoxy-cyclobutyl)-N-(2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl)-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / 0 - 25 °C

2.1: n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran; hexanes / 0.83 h / -78 - 0 °C / Cooling with acetone-dry ice

2.2: 21 h / -78 - 0 °C

With 1H-imidazole; n-butyllithium; iodine; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; hexanes; dichloromethane;