3-(iodomethyl)-1,1-dimethoxycyclobutane

Base Information

• Chemical Name: 3-(iodomethyl)-1,1-dimethoxycyclobutane
• CAS No.: 1003013-83-9
• Molecular Formula: C7H13 I O2
• Molecular Weight: 256.084
• Mol file: 1003013-83-9.mol

Synonyms:3-Iodomethyl-1,1-dimethoxycyclobutane

Chemical Property of 3-(iodomethyl)-1,1-dimethoxycyclobutane

Chemical Property:

• PSA: 18.46000
• LogP: 1.82050
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

3-(Iodomethyl)-1,1-dimethoxycyclobutane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(iodomethyl)-1,1-dimethoxycyclobutane

There total 3 articles about 3-(iodomethyl)-1,1-dimethoxycyclobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(3,3-bis-methoxy-cyclobutyl)methanol (175021-11-1) → 3-iodomethyl-1,1-dimethoxy-cyclobutane (1003013-83-9)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 0 - 25 ℃; for 2.5h;

Reference yield:

3-oxocyclobutanecarboxylic acid (23761-23-1) → 3-iodomethyl-1,1-dimethoxy-cyclobutane (1003013-83-9)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / methanol / 2 h / Heating / reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 17 h / 0 - 25 °C

3: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / 0 - 25 °C

With 1H-imidazole; lithium aluminium tetrahydride; iodine; triphenylphosphine; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

3,3-dimethoxycyclobutanecarboxylic acid methyl ester (98231-07-3) → 3-iodomethyl-1,1-dimethoxy-cyclobutane (1003013-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 17 h / 0 - 25 °C

2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / 0 - 25 °C

With 1H-imidazole; lithium aluminium tetrahydride; iodine; triphenylphosphine; In tetrahydrofuran; dichloromethane;

upstream raw materials:

(3,3-bis-methoxy-cyclobutyl)methanol

3-oxocyclobutanecarboxylic acid

3,3-dimethoxycyclobutanecarboxylic acid methyl ester

Downstream raw materials:

2(R)-(3-chloro-4-methylsulfanyl-phenyl)-3-(3,3-dimethoxy-cyclobutyl)-N-(2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl)-N-methyl-propionamide

2(R)-(3-chloro-4-methylsulfanyl-phenyl)-3-(3-oxo-cyclobutyl)-propionic acid

2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionic acid

2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-(3-oxo-cyclobutyl)-propionyl chloride

Refernces