2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel

Base Information

• Chemical Name: 2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel
• CAS No.: 162809-97-4
• Molecular Formula: C₅₇H₇₇NO₁₃Si₂
• Molecular Weight: 1040.41
• Mol file: 162809-97-4.mol

Synonyms:2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel

Chemical Property of 2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel

There total 6 articles about 2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.7%

triethylsilyl chloride (994-30-9) + 2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel (162375-26-0) → 2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel (162809-97-4)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

taxol (33069-62-4) → 2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel (162809-97-4)

Guidance literature:

Multi-step reaction with 3 steps

1: imidazole; DMAP

2: 79 percent / hydrazine

3: 85 percent / imidazole; DMAP

With 1H-imidazole; dmap; hydrazine;

DOI:10.1016/j.tetlet.2006.02.108

Reference yield:

2'-O-(tert-butyldimethylsilyl)paclitaxel (114655-02-6) → 2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel (162809-97-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / hydrazine

2: 85 percent / imidazole; DMAP

With 1H-imidazole; dmap; hydrazine;

DOI:10.1016/j.tetlet.2006.02.108

upstream raw materials:

triethylsilyl chloride

2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel

taxol

tert-butyldimethylsilyl chloride

Downstream raw materials:

C₆₄H₈₀N₂O₁₆Si₂

C₆₈H₁₀₁N₅O₁₄Si₂

C₆₂H₈₃NO₁₆Si₂

2-O-TES-7-O-methylthiomethyl-9-α-OH-10-epi-paclitaxel