2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel

Base Information

Chemical Name:2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel
CAS No.:162809-97-4
Molecular Formula:C₅₇H₇₇NO₁₃Si₂
Molecular Weight:1040.41
Hs Code.:

Synonyms:2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel

Suppliers and Price of 2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel

Chemical Property:

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Technology Process of 2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel

There total 6 articles about 2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.7%

: 994-30-9
triethylsilyl chloride

: 162375-26-0
2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel

: 162809-97-4
2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 33069-62-4
taxol

: 162809-97-4
2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole; DMAP

2: 79 percent / hydrazine

3: 85 percent / imidazole; DMAP

With 1H-imidazole; dmap; hydrazine;
DOI:10.1016/j.tetlet.2006.02.108

Reference yield:

: 114655-02-6
2'-O-(tert-butyldimethylsilyl)paclitaxel

: 162809-97-4
2'-O-(tert-butyldimethylsilyl)-10-deacetyl-7-O-triethylsilylpaclitaxel

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / hydrazine

2: 85 percent / imidazole; DMAP

With 1H-imidazole; dmap; hydrazine;
DOI:10.1016/j.tetlet.2006.02.108