Technology Process of 1-(trimethylsilyl)adamantane
There total 2 articles about 1-(trimethylsilyl)adamantane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium;
In
diethyl ether;
for 8h;
Ambient temperature;
- Guidance literature:
-
With
N,N,N,N,N,N-hexamethylphosphoric triamide; trimethylsilan; sodium;
In
diethyl ether;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium tert-butylate; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 3,4,7,8-Tetramethyl-o-phenanthrolin / tert-butyl methyl ether / 36 h / 110 °C / Glovebox; Sealed tube
1.2: 4 h / 20 °C
2.1: potassium methanolate / dimethyl sulfoxide / 8 h / 20 °C / Schlenk technique; Inert atmosphere
3.1: dihydrogen peroxide; potassium fluoride; potassium hydrogencarbonate / tetrahydrofuran; water; methanol / 15 h / 20 °C
With
potassium fluoride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 3,4,7,8-Tetramethyl-o-phenanthrolin; potassium methanolate; potassium tert-butylate; dihydrogen peroxide; potassium hydrogencarbonate;
In
tetrahydrofuran; methanol; tert-butyl methyl ether; water; dimethyl sulfoxide;
2.1: |Brook Silaketone Rearrangement;
DOI:10.1021/acs.joc.6b02917
