(+)-trans-2-(2-chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one

Base Information

Chemical Name:(+)-trans-2-(2-chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one
CAS No.:920113-01-5
Molecular Formula:C₂₃H₂₄ClNO₅
Molecular Weight:429.9
Hs Code.:

Synonyms:(+)-trans-2-(2-chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one

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Chemical Property of (+)-trans-2-(2-chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one

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Technology Process of (+)-trans-2-(2-chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one

There total 13 articles about (+)-trans-2-(2-chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.88%

: 610-96-8
methyl chlorobenzoate

: 920113-01-5
(+)-trans-2-(2-chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one

Guidance literature:: (-)-trans-1-[2-hydroxy-3-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-4,6-dimethoxyphenyl]-ethanone; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

methyl chlorobenzoate; In N,N-dimethyl-formamide; at 25 ℃; for 2h;

With hydrogenchloride; water; sodium carbonate; more than 3 stages;

Reference yield: 64.0%

: 610-96-8
methyl chlorobenzoate

: 920113-00-4
(-)-trans-1-[2-hydroxy-3-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-4,6-dimethoxyphenyl]-ethanone

: 920113-01-5
(+)-trans-2-(2-chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one

Guidance literature:: (-)-trans-1-[2-hydroxy-3-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-4,6-dimethoxyphenyl]-ethanone; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;

methyl chlorobenzoate; In N,N-dimethyl-formamide; at 25 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; at 20 ℃; for 2h;

Reference yield:

: 1622998-49-5
(-)-trans-2-(2-(acetoxymethyl)-1-methylpyrrolidin-3-yl)-6-acetyl-3,5-dimethoxyphenyl-2-chlorobenzoate

: 920113-01-5
(+)-trans-2-(2-chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one

Guidance literature:: (-)-trans-2-(2-(acetoxymethyl)-1-methylpyrrolidin-3-yl)-6-acetyl-3,5-dimethoxyphenyl-2-chlorobenzoate; With sodium hydride; In 2-methyltetrahydrofuran; at -5 - 0 ℃; Inert atmosphere;

With hydrogenchloride; water; at 25 - 30 ℃;